Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution

Tsung Ying Tsai; Li Wei Lo; Shin Huei Liu; Wen Han Cheng; Yu Hui Chou; Wei Lun Lin; Yenn Jiang Lin; Shih Lin Chang; Yu Feng Hu; Fa Po Chung; Jo Nan Liao; Tze Fan Chao; Shih Ann Chen

doi:10.1016/j.jelectrocard.2018.11.012

Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution

Tsung Ying Tsai, Li Wei Lo^*, Shin Huei Liu, Wen Han Cheng, Yu Hui Chou, Wei Lun Lin, Yenn Jiang Lin, Shih Lin Chang, Yu Feng Hu, Fa Po Chung, Jo Nan Liao, Tze Fan Chao, Shih Ann Chen

^*Corresponding author for this work

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear. Objective: We aimed to investigate the effect of PM2.5 (particulate matter < 2.5 μm in aerodynamic diameter) on the cardiac autonomics through a heart rate variability (HRV) analysis. Method: Among 6912 patients who had underwent 24-hour Holter ECG recordings between Oct 1st 2015 and Oct 31st 2016, 46 (25 males, 69.3 ± 12.1 years old) were enrolled with confirmation of living in an environment with a reported PM2.5 level and were classified as elevated (Group 1, >36 μg/m³, 50.73 ± 8.50) or low (Group 2, <11 μg/m³, 6.06 ± 1.00) PM2.5 group. The Holter recordings and HRV parameters were evaluated. Result: The baseline characteristics including the comorbidities and medications were similar between the 2 groups. The Holter ECG parameters were also similar. There were no significant HRV differences between the two groups for the 24-hour interval analysis. However, the LF/HF ratio was significantly higher in Group 1 than Group 2 in the 9 am to 9 pm (p = 0.028), 8 am to 4 pm (p = 0.024), and 4 pm to 12 pm (p = 0.025) periods, respectively, but not for the nocturnal HRV parameters. Conclusion: Our study demonstrated that an elevated PM2.5 exposure had a significant association with an increased daytime LF/HF ratio suggesting a diurnal difference in the response to PM2.5 exposure.

Original language	English
Pages (from-to)	112-116
Number of pages	5
Journal	Journal of Electrocardiology
Volume	52
DOIs	https://doi.org/10.1016/j.jelectrocard.2018.11.012
State	Published - 1 Jan 2019

Keywords

Arrhythmia
Autonomic
Diurnal
Heart rate variability
PM2.5

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10.1016/j.jelectrocard.2018.11.012

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Tsai, T. Y., Lo, L. W., Liu, S. H., Cheng, W. H., Chou, Y. H., Lin, W. L., Lin, Y. J., Chang, S. L., Hu, Y. F., Chung, F. P., Liao, J. N., Chao, T. F., & Chen, S. A. (2019). Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution. Journal of Electrocardiology, 52, 112-116. https://doi.org/10.1016/j.jelectrocard.2018.11.012

@article{e0b4edca80ff4e92bab4a99739622964,

title = "Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution",

abstract = "Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear. Objective: We aimed to investigate the effect of PM2.5 (particulate matter < 2.5 μm in aerodynamic diameter) on the cardiac autonomics through a heart rate variability (HRV) analysis. Method: Among 6912 patients who had underwent 24-hour Holter ECG recordings between Oct 1st 2015 and Oct 31st 2016, 46 (25 males, 69.3 ± 12.1 years old) were enrolled with confirmation of living in an environment with a reported PM2.5 level and were classified as elevated (Group 1, >36 μg/m3, 50.73 ± 8.50) or low (Group 2, <11 μg/m3, 6.06 ± 1.00) PM2.5 group. The Holter recordings and HRV parameters were evaluated. Result: The baseline characteristics including the comorbidities and medications were similar between the 2 groups. The Holter ECG parameters were also similar. There were no significant HRV differences between the two groups for the 24-hour interval analysis. However, the LF/HF ratio was significantly higher in Group 1 than Group 2 in the 9 am to 9 pm (p = 0.028), 8 am to 4 pm (p = 0.024), and 4 pm to 12 pm (p = 0.025) periods, respectively, but not for the nocturnal HRV parameters. Conclusion: Our study demonstrated that an elevated PM2.5 exposure had a significant association with an increased daytime LF/HF ratio suggesting a diurnal difference in the response to PM2.5 exposure.",

keywords = "Arrhythmia, Autonomic, Diurnal, Heart rate variability, PM2.5",

author = "Tsai, {Tsung Ying} and Lo, {Li Wei} and Liu, {Shin Huei} and Cheng, {Wen Han} and Chou, {Yu Hui} and Lin, {Wei Lun} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Hu, {Yu Feng} and Chung, {Fa Po} and Liao, {Jo Nan} and Chao, {Tze Fan} and Chen, {Shih Ann}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.jelectrocard.2018.11.012",

language = "English",

volume = "52",

pages = "112--116",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution

AU - Tsai, Tsung Ying

AU - Lo, Li Wei

AU - Liu, Shin Huei

AU - Cheng, Wen Han

AU - Chou, Yu Hui

AU - Lin, Wei Lun

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Hu, Yu Feng

AU - Chung, Fa Po

AU - Liao, Jo Nan

AU - Chao, Tze Fan

AU - Chen, Shih Ann

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear. Objective: We aimed to investigate the effect of PM2.5 (particulate matter < 2.5 μm in aerodynamic diameter) on the cardiac autonomics through a heart rate variability (HRV) analysis. Method: Among 6912 patients who had underwent 24-hour Holter ECG recordings between Oct 1st 2015 and Oct 31st 2016, 46 (25 males, 69.3 ± 12.1 years old) were enrolled with confirmation of living in an environment with a reported PM2.5 level and were classified as elevated (Group 1, >36 μg/m3, 50.73 ± 8.50) or low (Group 2, <11 μg/m3, 6.06 ± 1.00) PM2.5 group. The Holter recordings and HRV parameters were evaluated. Result: The baseline characteristics including the comorbidities and medications were similar between the 2 groups. The Holter ECG parameters were also similar. There were no significant HRV differences between the two groups for the 24-hour interval analysis. However, the LF/HF ratio was significantly higher in Group 1 than Group 2 in the 9 am to 9 pm (p = 0.028), 8 am to 4 pm (p = 0.024), and 4 pm to 12 pm (p = 0.025) periods, respectively, but not for the nocturnal HRV parameters. Conclusion: Our study demonstrated that an elevated PM2.5 exposure had a significant association with an increased daytime LF/HF ratio suggesting a diurnal difference in the response to PM2.5 exposure.

AB - Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear. Objective: We aimed to investigate the effect of PM2.5 (particulate matter < 2.5 μm in aerodynamic diameter) on the cardiac autonomics through a heart rate variability (HRV) analysis. Method: Among 6912 patients who had underwent 24-hour Holter ECG recordings between Oct 1st 2015 and Oct 31st 2016, 46 (25 males, 69.3 ± 12.1 years old) were enrolled with confirmation of living in an environment with a reported PM2.5 level and were classified as elevated (Group 1, >36 μg/m3, 50.73 ± 8.50) or low (Group 2, <11 μg/m3, 6.06 ± 1.00) PM2.5 group. The Holter recordings and HRV parameters were evaluated. Result: The baseline characteristics including the comorbidities and medications were similar between the 2 groups. The Holter ECG parameters were also similar. There were no significant HRV differences between the two groups for the 24-hour interval analysis. However, the LF/HF ratio was significantly higher in Group 1 than Group 2 in the 9 am to 9 pm (p = 0.028), 8 am to 4 pm (p = 0.024), and 4 pm to 12 pm (p = 0.025) periods, respectively, but not for the nocturnal HRV parameters. Conclusion: Our study demonstrated that an elevated PM2.5 exposure had a significant association with an increased daytime LF/HF ratio suggesting a diurnal difference in the response to PM2.5 exposure.

KW - Arrhythmia

KW - Autonomic

KW - Diurnal

KW - Heart rate variability

KW - PM2.5

UR - http://www.scopus.com/inward/record.url?scp=85058230710&partnerID=8YFLogxK

U2 - 10.1016/j.jelectrocard.2018.11.012

DO - 10.1016/j.jelectrocard.2018.11.012

M3 - Article

C2 - 30553983

AN - SCOPUS:85058230710

SN - 0022-0736

VL - 52

SP - 112

EP - 116

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

ER -

Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution

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Keywords

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