Distinctive clinicopathological features of Ki-ras mutated colorectal cancers

Jen Kou Lin*, Shih Ching Chang, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Wei Chone Chen, Tzu Chen Lin, Anna Fen Yau Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background and Objectives: We explored the relationship between the mutation pattern of Ki-ras and the clinicopathological features of colorectal cancers (CRCs). Methods: Relationships between clinicopathological parameters and Ki-ras mutation status were analyzed in 255 CRC patients using the chi-square and student t-tests. Kaplan-Meier survival curves were compared using the log-rank test. Results: Ki-ras mutation occurred in 43.9% of tumors, and 83% affected codon 12. The most frequent mutations were GGT->GAT (Gly->Asp) (37.5%), followed by GGT->GTT (Gly->Val) (31.3%), both in codon 12. The frequency of Ki-ras mutation was similar for different tumor stages (38.2-47.8%). The mucin component of tumors was significantly associated with Ki-ras mutation. The 4-year overall and disease-free survival was 61% and 54%, respectively, for patients with Ki-ras mutated tumors, and 73% and 60% for patients with nonmutated tumors (not statistically significant). Patients with Ki-ras mutated tumors had lower plasma folate (24 ng/dl) than those bearing nonmutated tumors (37 ng/dl). Patients with G->T Ki-ras mutations had the lowest folate level (22 ng/dl), followed by those with G->A mutations (25 ng/dl). Conclusions: Ki-ras mutated colorectal tumors have a higher mucin production and higher differentiation, and are associated with lower plasma folate levels and a relatively poorer disease outcome.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalJournal of Surgical Oncology
Issue number3
StatePublished - 1 Sep 2006


  • Colorectal cancer
  • Folate
  • Ki-ras


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