Distinct characteristics of escherichia coli isolated from patients with urinary tract infections in a medical center at a ten-year interval

Wei Hung Lin, Yen Zhen Zhang, Po Yao Liu, Po Shun Chen, Shi Ning Wang, Pei Yun Kuo, Tran Thi Dieu Thuy, Tran Thi Thuy Duong, Li Li Wen, Yi Hsien Hsieh, Ming Cheng Wang*, Cheng Yen Kao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Escherichia coli causing urinary tract infections (UTIs) are one of the most common out-patient bacterial infections. This study aimed to compare the characteristics of E. coli isolated from UTI patients in a single medical center in 2009–2010 (n = 504) and 2020 (n = 340). The antimicrobial susceptibility of E. coli was determined by the disk diffusion method. PCRs were conducted to detect phylogenetic groups, ST131, K1 capsule antigen, and 15 virulence factors. Phylogenetic group B2 dominated in our 2009–2010 and 2020 isolates. Moreover, no phylogenetic group E strains were isolated in 2020. E. coli isolates in 2020 were more susceptible to amoxicillin, ampicillin/sulbactam, cefuroxime, cefmetazole, ceftazidime, cefoxitin, tetracycline, and sulfamethoxazole/trimethoprim, compared to the isolates in 2009–2010. Extensively drug-resistant (XDR)-E. coli in 2009–2010 were detected in groups B1 (5 isolates), B2 (12 isolates), F (8 isolates), and unknown (1 isolate). In 2020, XDR-E. coli were only detected in groups A (2 isolates), B2 (5 isolates), D (1 isolate), and F (4 isolates). The prevalence of virulence factor genes aer and fimH were higher in E. coli in 2009–2010 compared to those in 2020. In contrast, afa and sat showed higher frequencies in E. coli isolates in 2020 compared to E. coli in 2009–2010.

Original languageEnglish
Article number1156
JournalPathogens
Volume10
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • Antimicrobial susceptibility
  • Longitudinal surveillance
  • Phylogenetic groups
  • Urinary tract infections
  • Virulence factors

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