Directly thiolated modification onto the surface of detonation nanodiamonds

Ming Hua Hsu*, Hong Chuang, Fong Yu Cheng, Ying Pei Huang, Chien Chung Han, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Dian Syue Wu, Hsueh Liang Chu, Chia-Ching Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

Original languageEnglish
Pages (from-to)7198-7203
Number of pages6
JournalACS Applied Materials and Interfaces
Issue number10
StatePublished - 28 May 2014


  • detonation nanodiamond
  • functionalized nanodiamond
  • nanodiamond
  • surface modification
  • thiolated
  • thiolated nanodiamond


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