Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process

Hsin Yu Lin, Chu Chung Huang*, Kun Hsien Chou, Albert C. Yang, Chun Yi Zac Lo, Shih Jen Tsai, Ching Po Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The cerebral cortex is a highly convoluted structure with distinct morphologic features, namely the gyri and sulci, which are associated with the functional segregation or integration in the human brain. During the lifespan, the brain atrophy that is accompanied by cognitive decline is a well-accepted aging phenotype. However, the detailed patterns of cortical folding change during aging, especially the changing age-dependencies of gyri and sulci, which is essential to brain functioning, remain unclear. In this study, we investigated the morphology of the gyral and sulcal regions from pial and white matter surfaces using MR imaging data of 417 healthy participants across adulthood to old age (21–92 years). To elucidate the age-related changes in the cortical pattern, we fitted cortical thickness and intrinsic curvature of gyri and sulci using the quadratic model to evaluate their age-dependencies during normal aging. Our findings show that comparing to gyri, the sulcal thinning is the most prominent pattern during the aging process, and the gyrification of pial and white matter surfaces were also affected differently, which implies the vulnerability of functional segregation during aging. Taken together, we propose a morphological model of aging that may provide a framework for understanding the mechanisms underlying gray matter degeneration.

Original languageEnglish
Article number625931
JournalFrontiers in Aging Neuroscience
Volume13
DOIs
StatePublished - 3 Feb 2021

Keywords

  • aging
  • cortical thickness
  • gyri and sulci
  • gyrification
  • intrinsic curvature

Fingerprint

Dive into the research topics of 'Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process'. Together they form a unique fingerprint.

Cite this