Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping

Shi Ying Ke; Ken Pen Weng; Meng Chu Chang; Ming Ting Wu; Yi He Li; Kuang Jen Chien; Chu Chuan Lin; Kai Sheng Hsieh; Ming Hua Chang; Jun Yen Pan; Hsu Hsia Peng

doi:10.1002/jmri.28420

Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping

Shi Ying Ke, Ken Pen Weng, Meng Chu Chang, Ming Ting Wu^*, Yi He Li, Kuang Jen Chien, Chu Chuan Lin, Kai Sheng Hsieh, Ming Hua Chang, Jun Yen Pan, Hsu Hsia Peng^*

^*Corresponding author for this work

Department of Radiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients. Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM). Study Type: Prospective. Population: A total of 49 rTOF patients (23 ± 5 years old; male = 32), 47 normal controls (22 ± 1 year old; male = 29). Field Strength/Sequence: 3-T/2D dark-blood three-directional velocity-encoded gradient-echo sequence. Assessment: Left and right ventricle (LV, RV) myocardial KE in radial (KE_r), circumferential (KE_ø), longitudinal (KE_z) directions. The proportions of KE in each direction to the sum of all KE (KE_røz): %KE_r, %KE_ø, %KE_z. PR fraction. Statistical Test: Student's t test, multivariable regression. Statistical significance: P < 0.05. Results: In rTOF group, LV KE_z remained normal in systole (P = 0.565) and diastole (P = 0.210), whereas diastolic LV %KE_z (62% ± 14% vs. 72% ± 7%) and systolic LV %KE_ø (9% ± 6% vs. 20% ± 7%) were significantly decreased. The KE_r and %KE_r of both ventricles significantly increased in the rTOF group (RV in diastole: 6 ± 3 vs. 3 ± 1 μJ and 54% ± 13% vs. 27% ± 7%). The rTOF group exhibited significantly higher RV/LV ratios of %KE_r (systole: 1.3 ± 0.3 vs. 1.0 ± 0.3) and %KE_ø (systole: 1.6 ± 0.8 vs. 1.0 ± 0.3) and significantly lower ratios of %KE_z in systole (0.7 ± 0.2 vs. 1.0 ± 0.1) and diastole (0.5 ± 0.2 vs. 0.9 ± 0.1). In multivariable regression analysis, the RV peak systolic KE_røz, RV systolic KE_z, and LV diastolic %KE_ø were independently associated with PR fraction in the rTOF group (adjusted R² = 0.479). Data Conclusion: In rTOF patients, the adaptation of the KE proportion occurred earlier than that of the KE amplitude, and the biventricular balance of %KE was disrupted. PR may cause differential KE adaptation in RV and LV. TPM-derived KE may be useful in investigation of myocardial adaptation in rTOF patients. Evidence Level: 2. Technical Efficacy: Stage 3.

Original language	English
Pages (from-to)	1492-1504
Number of pages	13
Journal	Journal of Magnetic Resonance Imaging
Volume	57
Issue number	5
DOIs	https://doi.org/10.1002/jmri.28420
State	Published - May 2023

Keywords

kinetic energy
myocardium
pulmonary regurgitation
tetralogy of Fallot

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10.1002/jmri.28420

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Ke, S. Y., Weng, K. P., Chang, M. C., Wu, M. T., Li, Y. H., Chien, K. J., Lin, C. C., Hsieh, K. S., Chang, M. H., Pan, J. Y., & Peng, H. H. (2023). Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping. Journal of Magnetic Resonance Imaging, 57(5), 1492-1504. https://doi.org/10.1002/jmri.28420

@article{c442e7d0db244b7ba4059375f4a4f92e,

title = "Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping",

abstract = "Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients. Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM). Study Type: Prospective. Population: A total of 49 rTOF patients (23 ± 5 years old; male = 32), 47 normal controls (22 ± 1 year old; male = 29). Field Strength/Sequence: 3-T/2D dark-blood three-directional velocity-encoded gradient-echo sequence. Assessment: Left and right ventricle (LV, RV) myocardial KE in radial (KEr), circumferential (KE{\o}), longitudinal (KEz) directions. The proportions of KE in each direction to the sum of all KE (KEr{\o}z): %KEr, %KE{\o}, %KEz. PR fraction. Statistical Test: Student's t test, multivariable regression. Statistical significance: P < 0.05. Results: In rTOF group, LV KEz remained normal in systole (P = 0.565) and diastole (P = 0.210), whereas diastolic LV %KEz (62% ± 14% vs. 72% ± 7%) and systolic LV %KE{\o} (9% ± 6% vs. 20% ± 7%) were significantly decreased. The KEr and %KEr of both ventricles significantly increased in the rTOF group (RV in diastole: 6 ± 3 vs. 3 ± 1 μJ and 54% ± 13% vs. 27% ± 7%). The rTOF group exhibited significantly higher RV/LV ratios of %KEr (systole: 1.3 ± 0.3 vs. 1.0 ± 0.3) and %KE{\o} (systole: 1.6 ± 0.8 vs. 1.0 ± 0.3) and significantly lower ratios of %KEz in systole (0.7 ± 0.2 vs. 1.0 ± 0.1) and diastole (0.5 ± 0.2 vs. 0.9 ± 0.1). In multivariable regression analysis, the RV peak systolic KEr{\o}z, RV systolic KEz, and LV diastolic %KE{\o} were independently associated with PR fraction in the rTOF group (adjusted R2 = 0.479). Data Conclusion: In rTOF patients, the adaptation of the KE proportion occurred earlier than that of the KE amplitude, and the biventricular balance of %KE was disrupted. PR may cause differential KE adaptation in RV and LV. TPM-derived KE may be useful in investigation of myocardial adaptation in rTOF patients. Evidence Level: 2. Technical Efficacy: Stage 3.",

keywords = "kinetic energy, myocardium, pulmonary regurgitation, tetralogy of Fallot",

author = "Ke, {Shi Ying} and Weng, {Ken Pen} and Chang, {Meng Chu} and Wu, {Ming Ting} and Li, {Yi He} and Chien, {Kuang Jen} and Lin, {Chu Chuan} and Hsieh, {Kai Sheng} and Chang, {Ming Hua} and Pan, {Jun Yen} and Peng, {Hsu Hsia}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.",

year = "2023",

month = may,

doi = "10.1002/jmri.28420",

language = "English",

volume = "57",

pages = "1492--1504",

journal = "Journal of Magnetic Resonance Imaging",

issn = "1053-1807",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping

AU - Ke, Shi Ying

AU - Weng, Ken Pen

AU - Chang, Meng Chu

AU - Wu, Ming Ting

AU - Li, Yi He

AU - Chien, Kuang Jen

AU - Lin, Chu Chuan

AU - Hsieh, Kai Sheng

AU - Chang, Ming Hua

AU - Pan, Jun Yen

AU - Peng, Hsu Hsia

PY - 2023/5

Y1 - 2023/5

N2 - Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients. Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM). Study Type: Prospective. Population: A total of 49 rTOF patients (23 ± 5 years old; male = 32), 47 normal controls (22 ± 1 year old; male = 29). Field Strength/Sequence: 3-T/2D dark-blood three-directional velocity-encoded gradient-echo sequence. Assessment: Left and right ventricle (LV, RV) myocardial KE in radial (KEr), circumferential (KEø), longitudinal (KEz) directions. The proportions of KE in each direction to the sum of all KE (KErøz): %KEr, %KEø, %KEz. PR fraction. Statistical Test: Student's t test, multivariable regression. Statistical significance: P < 0.05. Results: In rTOF group, LV KEz remained normal in systole (P = 0.565) and diastole (P = 0.210), whereas diastolic LV %KEz (62% ± 14% vs. 72% ± 7%) and systolic LV %KEø (9% ± 6% vs. 20% ± 7%) were significantly decreased. The KEr and %KEr of both ventricles significantly increased in the rTOF group (RV in diastole: 6 ± 3 vs. 3 ± 1 μJ and 54% ± 13% vs. 27% ± 7%). The rTOF group exhibited significantly higher RV/LV ratios of %KEr (systole: 1.3 ± 0.3 vs. 1.0 ± 0.3) and %KEø (systole: 1.6 ± 0.8 vs. 1.0 ± 0.3) and significantly lower ratios of %KEz in systole (0.7 ± 0.2 vs. 1.0 ± 0.1) and diastole (0.5 ± 0.2 vs. 0.9 ± 0.1). In multivariable regression analysis, the RV peak systolic KErøz, RV systolic KEz, and LV diastolic %KEø were independently associated with PR fraction in the rTOF group (adjusted R2 = 0.479). Data Conclusion: In rTOF patients, the adaptation of the KE proportion occurred earlier than that of the KE amplitude, and the biventricular balance of %KE was disrupted. PR may cause differential KE adaptation in RV and LV. TPM-derived KE may be useful in investigation of myocardial adaptation in rTOF patients. Evidence Level: 2. Technical Efficacy: Stage 3.

AB - Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients. Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM). Study Type: Prospective. Population: A total of 49 rTOF patients (23 ± 5 years old; male = 32), 47 normal controls (22 ± 1 year old; male = 29). Field Strength/Sequence: 3-T/2D dark-blood three-directional velocity-encoded gradient-echo sequence. Assessment: Left and right ventricle (LV, RV) myocardial KE in radial (KEr), circumferential (KEø), longitudinal (KEz) directions. The proportions of KE in each direction to the sum of all KE (KErøz): %KEr, %KEø, %KEz. PR fraction. Statistical Test: Student's t test, multivariable regression. Statistical significance: P < 0.05. Results: In rTOF group, LV KEz remained normal in systole (P = 0.565) and diastole (P = 0.210), whereas diastolic LV %KEz (62% ± 14% vs. 72% ± 7%) and systolic LV %KEø (9% ± 6% vs. 20% ± 7%) were significantly decreased. The KEr and %KEr of both ventricles significantly increased in the rTOF group (RV in diastole: 6 ± 3 vs. 3 ± 1 μJ and 54% ± 13% vs. 27% ± 7%). The rTOF group exhibited significantly higher RV/LV ratios of %KEr (systole: 1.3 ± 0.3 vs. 1.0 ± 0.3) and %KEø (systole: 1.6 ± 0.8 vs. 1.0 ± 0.3) and significantly lower ratios of %KEz in systole (0.7 ± 0.2 vs. 1.0 ± 0.1) and diastole (0.5 ± 0.2 vs. 0.9 ± 0.1). In multivariable regression analysis, the RV peak systolic KErøz, RV systolic KEz, and LV diastolic %KEø were independently associated with PR fraction in the rTOF group (adjusted R2 = 0.479). Data Conclusion: In rTOF patients, the adaptation of the KE proportion occurred earlier than that of the KE amplitude, and the biventricular balance of %KE was disrupted. PR may cause differential KE adaptation in RV and LV. TPM-derived KE may be useful in investigation of myocardial adaptation in rTOF patients. Evidence Level: 2. Technical Efficacy: Stage 3.

KW - kinetic energy

KW - myocardium

KW - pulmonary regurgitation

KW - tetralogy of Fallot

UR - http://www.scopus.com/inward/record.url?scp=85137858576&partnerID=8YFLogxK

U2 - 10.1002/jmri.28420

DO - 10.1002/jmri.28420

M3 - Article

C2 - 36094105

AN - SCOPUS:85137858576

SN - 1053-1807

VL - 57

SP - 1492

EP - 1504

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 5

ER -

Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping

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