TY - JOUR
T1 - Differences in gene mutations according to gender among patients with colorectal cancer
AU - Tsai, Yi Jian
AU - Huang, Sheng Chieh
AU - Lin, Hung Hsin
AU - Lin, Chun Chi
AU - Lan, Yuan Tzu
AU - Wang, Huann Sheng
AU - Yang, Shung Haur
AU - Jiang, Jeng Kai
AU - Chen, Wei Shone
AU - Lin, Tzu chen
AU - Lin, Jen Kou
AU - Chang, Shih Ching
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/5
Y1 - 2018/7/5
N2 - Background: The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods: A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans' General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results: There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion: Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.
AB - Background: The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods: A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans' General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results: There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion: Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.
KW - Colorectal cancer
KW - Gender
KW - Gene mutation
UR - http://www.scopus.com/inward/record.url?scp=85049589731&partnerID=8YFLogxK
U2 - 10.1186/s12957-018-1431-5
DO - 10.1186/s12957-018-1431-5
M3 - Article
C2 - 29976257
AN - SCOPUS:85049589731
SN - 1477-7819
VL - 16
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
IS - 1
M1 - 128
ER -
