Diagnostic laboratory tests

Ying Ying Yang*, Han Chieh Lin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Although there is no single biomarker for liver cirrhosis, abnormalities in serologic laboratory tests may suggest the presence of liver cirrhosis and indicate its severity. For example, we need to check for cirrhosis in patients with nonalcoholic liver disease, while the serum AST: ALT ratio is above 1. The severity of hyponatremia is positively correlated with the severity of liver cirrhosis. In addition, the serum level of bilirubin and, albumin as well as prothrombin time can effectively predict the survival probability of cirrhotic patients while they are used as parameters of Child-Pugh score. On the other hand, there are other tests that specifically diagnose certain etiologies of liver cirrhosis, such as serum ceruloplasmin level for Wilson's disease whereas antimitochondrial autoantibody for primary biliary cirrhosis. Therefore, it is important to pay more attention to these diagnostic laboratory tests when evaluating patients with liver cirrhosis.

Original languageEnglish
Title of host publicationCirrhosis
Subtitle of host publicationA Practical Guide to Management
Number of pages9
ISBN (Electronic)9781118412640
ISBN (Print)9781118274828
StatePublished - 30 Jan 2015


  • Albumin
  • Ammonia
  • AST: ALT ratio
  • Bilirubin
  • Hyponatremia
  • Laboratory tests
  • Liver cirrhosis
  • Prothrombin time
  • Thrombocytopenia


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