TY - JOUR
T1 - Diabetes and 15-year Cardiovascular Mortality in a Chinese Population
T2 - Differential Impact of Hypertension and Metabolic Syndrome
AU - Chuang, Shao Yuan
AU - Hsu, Pai Feng
AU - Sung, Shih Hsien
AU - Chou, Pesus
AU - Chen, Chen Huan
N1 - Funding Information:
This work was supported in part by a grant from the National Science Council (NSC 96-2314-B-010-035-MY3), an intramural grant from Taipei Veterans General Hospital (grant no. V98C1-028), and grants in aid from the Research Foundation of Cardiovascular Medicine, Taipei, Taiwan, R.O.C.
PY - 2010/5
Y1 - 2010/5
N2 - Background: It remains unclear if the risk for cardiovascular (CV) mortality in patients with diabetes mellitus (DM) is equivalent to that in patients with a history of cardiac disease in Asian populations. The aims of the present study were to investigate whether or not non-heart disease (HD) DM subjects have a similar risk of CV mortality as HD patients without DM (non-DM HD), and whether or not hypertension (HT) or metabolic syndrome (MS) is a CV mortality marker for diabetic subjects identified from a community-based population. Methods: We followed 11,058 Chinese people aged ≥ 30 years on Kinmen island for a median of 15.0 years. Results: The age-, sex- and smoking-adjusted hazard ratios for CV mortality were 3.56 [95% confidence interval (CI): 1.99-6.36] for DM subjects with HD, 1.64 (95% CI: 1.25-2.16) for DM without HD (non-HD DM) subjects, and 1.63 (95% CI: 1.09-2.44) for non-DM HD patients, when compared with subjects without DM and HD. Among the 827 non-HD DM subjects identified at the baseline survey, the age-, sex- and smoking-adjusted hazard ratios for CV mortality were 2.36 (95% CI: 1.30-4.28) for the presence versus absence of HT, and 1.23 (95% CI: 0.65-2.34) for the presence versus absence of MS. Conclusion: Non-HD DM subjects had a similar risk of CV mortality to non-DM HD subjects in this Chinese population. The presence of HT but not MS substantially increased CV mortality risk in the DM subjects.
AB - Background: It remains unclear if the risk for cardiovascular (CV) mortality in patients with diabetes mellitus (DM) is equivalent to that in patients with a history of cardiac disease in Asian populations. The aims of the present study were to investigate whether or not non-heart disease (HD) DM subjects have a similar risk of CV mortality as HD patients without DM (non-DM HD), and whether or not hypertension (HT) or metabolic syndrome (MS) is a CV mortality marker for diabetic subjects identified from a community-based population. Methods: We followed 11,058 Chinese people aged ≥ 30 years on Kinmen island for a median of 15.0 years. Results: The age-, sex- and smoking-adjusted hazard ratios for CV mortality were 3.56 [95% confidence interval (CI): 1.99-6.36] for DM subjects with HD, 1.64 (95% CI: 1.25-2.16) for DM without HD (non-HD DM) subjects, and 1.63 (95% CI: 1.09-2.44) for non-DM HD patients, when compared with subjects without DM and HD. Among the 827 non-HD DM subjects identified at the baseline survey, the age-, sex- and smoking-adjusted hazard ratios for CV mortality were 2.36 (95% CI: 1.30-4.28) for the presence versus absence of HT, and 1.23 (95% CI: 0.65-2.34) for the presence versus absence of MS. Conclusion: Non-HD DM subjects had a similar risk of CV mortality to non-DM HD subjects in this Chinese population. The presence of HT but not MS substantially increased CV mortality risk in the DM subjects.
KW - cardiovascular mortality
KW - cardiovascular risk equivalent
KW - diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=77952833625&partnerID=8YFLogxK
U2 - 10.1016/S1726-4901(10)70051-4
DO - 10.1016/S1726-4901(10)70051-4
M3 - Article
C2 - 20685589
AN - SCOPUS:77952833625
SN - 1726-4901
VL - 73
SP - 234
EP - 240
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 5
ER -
