Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Ming Hsien Chan, Chen Yu Lai, Yung Chieh Chan, Michael Hsiao, Ren Jei Chung, Xueyuan Chen, Ru Shi Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

Original languageEnglish
Pages (from-to)1791-1804
Number of pages14
JournalNanomedicine
Volume14
Issue number14
DOIs
StatePublished - Jul 2019

Keywords

  • bio-conjugating
  • indium phosphide quantum dots
  • MMP2 sensing
  • Nd-sensitized upconversion nanoparticles
  • targeting

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