Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Ming Hsien Chan; Chen Yu Lai; Yung Chieh Chan; Michael Hsiao; Ren Jei Chung; Xueyuan Chen; Ru Shi Liu

doi:10.2217/nnm-2018-0524

Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Ming Hsien Chan, Chen Yu Lai, Yung Chieh Chan, Michael Hsiao, Ren Jei Chung, Xueyuan Chen, Ru Shi Liu^*

^*Corresponding author for this work

Department of Biomedical Imaging and Radiological Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

Original language	English
Pages (from-to)	1791-1804
Number of pages	14
Journal	Nanomedicine
Volume	14
Issue number	14
DOIs	https://doi.org/10.2217/nnm-2018-0524
State	Published - Jul 2019

Keywords

MMP2 sensing
Nd-sensitized upconversion nanoparticles
bio-conjugating
indium phosphide quantum dots
targeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2018-0524

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@article{5dc7ba30cfaa420c83c2be3f450419bb,

title = "Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing",

abstract = "Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.",

keywords = "MMP2 sensing, Nd-sensitized upconversion nanoparticles, bio-conjugating, indium phosphide quantum dots, targeting",

author = "Chan, {Ming Hsien} and Lai, {Chen Yu} and Chan, {Yung Chieh} and Michael Hsiao and Chung, {Ren Jei} and Xueyuan Chen and Liu, {Ru Shi}",

note = "Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",

year = "2019",

month = jul,

doi = "10.2217/nnm-2018-0524",

language = "English",

volume = "14",

pages = "1791--1804",

journal = "Nanomedicine",

issn = "1743-5889",

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TY - JOUR

T1 - Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

AU - Chan, Ming Hsien

AU - Lai, Chen Yu

AU - Chan, Yung Chieh

AU - Hsiao, Michael

AU - Chung, Ren Jei

AU - Chen, Xueyuan

AU - Liu, Ru Shi

PY - 2019/7

Y1 - 2019/7

N2 - Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

AB - Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

KW - MMP2 sensing

KW - Nd-sensitized upconversion nanoparticles

KW - bio-conjugating

KW - indium phosphide quantum dots

KW - targeting

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DO - 10.2217/nnm-2018-0524

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AN - SCOPUS:85069873838

SN - 1743-5889

VL - 14

SP - 1791

EP - 1804

JO - Nanomedicine

JF - Nanomedicine

IS - 14

ER -

Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Abstract

Keywords

UN SDGs

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