Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Lin Chiang Sherlock Huang; Hong Chuang; Mohit Kapoor; Cheng Ying Hsieh; Shih Ching Chou; Hui Hsien Lin; Yi Wei Chen; Chia-Ching Chang; Jih Ru Hwu; Yu Chuan Liang; Ming Hua Hsu

doi:10.1039/c5ra18827j

Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Lin Chiang Sherlock Huang, Hong Chuang, Mohit Kapoor, Cheng Ying Hsieh, Shih Ching Chou, Hui Hsien Lin, Yi Wei Chen, Chia-Ching Chang, Jih Ru Hwu^*, Yu Chuan Liang, Ming Hua Hsu

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M₄N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

Original language	English
Pages (from-to)	107833-107838
Number of pages	6
Journal	RSC Advances
Volume	5
Issue number	130
DOIs	https://doi.org/10.1039/c5ra18827j
State	Published - 15 Dec 2015

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title = "Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment",

abstract = "In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.",

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AU - Huang, Lin Chiang Sherlock

AU - Chuang, Hong

AU - Kapoor, Mohit

AU - Hsieh, Cheng Ying

AU - Chou, Shih Ching

AU - Lin, Hui Hsien

AU - Chen, Yi Wei

AU - Chang, Chia-Ching

AU - Hwu, Jih Ru

AU - Liang, Yu Chuan

AU - Hsu, Ming Hua

PY - 2015/12/15

Y1 - 2015/12/15

N2 - In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

AB - In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

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JO - RSC Advances

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IS - 130

ER -

Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Abstract

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