Development of an optical biosensor for the determination of choline in human biofluids

Raja Lavanya; Venkatesan Srinivasadesikan; Ming chang Lin; Vediappen Padmini

doi:10.1016/j.molstruc.2023.135040

Development of an optical biosensor for the determination of choline in human biofluids

Raja Lavanya, Venkatesan Srinivasadesikan, Ming chang Lin, Vediappen Padmini^*

^*Corresponding author for this work

2 Scopus citations

Abstract

An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.

Original language	English
Article number	135040
Journal	Journal of Molecular Structure
Volume	1280
DOIs	https://doi.org/10.1016/j.molstruc.2023.135040
State	Published - 15 May 2023

Keywords

Chalcone derivative
Choline
Choline biosensor
Low detection limit

Access to Document

10.1016/j.molstruc.2023.135040

Cite this

@article{6ecf4452b59e49bba657c0353a980238,

title = "Development of an optical biosensor for the determination of choline in human biofluids",

abstract = "An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.",

keywords = "Chalcone derivative, Choline, Choline biosensor, Low detection limit",

author = "Raja Lavanya and Venkatesan Srinivasadesikan and Lin, {Ming chang} and Vediappen Padmini",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = may,

day = "15",

doi = "10.1016/j.molstruc.2023.135040",

language = "English",

volume = "1280",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier",

}

TY - JOUR

T1 - Development of an optical biosensor for the determination of choline in human biofluids

AU - Lavanya, Raja

AU - Srinivasadesikan, Venkatesan

AU - Lin, Ming chang

AU - Padmini, Vediappen

PY - 2023/5/15

Y1 - 2023/5/15

N2 - An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.

AB - An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.

KW - Chalcone derivative

KW - Choline

KW - Choline biosensor

KW - Low detection limit

UR - http://www.scopus.com/inward/record.url?scp=85150820773&partnerID=8YFLogxK

U2 - 10.1016/j.molstruc.2023.135040

DO - 10.1016/j.molstruc.2023.135040

M3 - Article

AN - SCOPUS:85150820773

SN - 0022-2860

VL - 1280

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 135040

ER -

Development of an optical biosensor for the determination of choline in human biofluids

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this