Development of an Albumin-Masked mutPD-1Ig as a Tumor Lesion-Selective Immune Checkpoint Inhibitor

Keyphrases

• Adverse Events 25%
• Albumin 100%
• Antitumor Effect 25%
• Binding Activity 50%
• Binding Motif 25%
• Bioinformatics Tools 25%
• Cancer Treatment 25%
• Digestion 25%
• Hereafter 25%
• Immune Checkpoint Inhibitors 100%
• Linker 25%
• Mask Efficiency 50%
• N-terminus 50%
• Programmed Death-ligand 1 (PD-L1) 25%
• Protease 25%
• Starting Position 25%
• Tumor 25%
• Tumor-like Lesions 100%
• Type IV Collagen 25%
• Validation Experiment 25%

Biochemistry, Genetics and Molecular Biology

• Binding Affinity 66%
• Gelatinase A 33%
• Immune Checkpoints 100%
• Immunity 33%
• Masking 66%
• MMP2 33%
• N-Terminus 66%
• Protease 33%

Immunology and Microbiology

• Amino Terminal Sequence 50%
• Binding Affinity 50%
• Immunity 100%
• Masking 50%