Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

Hsueh Liang Chu, Hung Wei Chen, Shin Hua Tseng, Ming Hua Hsu, Li Ping Ho, Fu Hsuan Chou, Md Phd Hsing Yuan Li, Yu Chuan Chang, Pei Hsin Chen, Li Yun Tsai, Ching Chung Chou, Jyh Shin Chen, Tsai Mu Cheng*, Chia-Ching Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a "nanoblast" and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages8
Issue number5
StatePublished - May 2014


  • A549 lung cancer cells
  • apoptosis
  • lasers
  • nanodiamond complexes
  • recombinant growth hormones


Dive into the research topics of 'Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy'. Together they form a unique fingerprint.

Cite this