@inproceedings{6006655f23d4499f9dde2cbfa5b1f46f,
title = "Detection of KCl Induced Cortical Spreading Depolarization (CSD) with Dynamic Ultrafast Doppler",
abstract = "Cortical spreading depolarization (CSD) reflects neuronal depolarization slowly propagating in the cortex and is accompanied with vascular response. Dynamic ultrafast Doppler has potential to access the hemodynamic response to CSD, specifically to the penetrating vessels in the cortex. In this study, the CSD was experimentally triggered by topical application of potassium chloride (KCl) on the surface of the brain. The vascular response caused by KCl induced CSD was successfully detected during the dynamic ultrafast Doppler. The propagation of vascular responses from the center of right cortex (stimulated side) to the medial and lateral side was observed. The perfusion change (ΔCBV) decreased over 30 % from the baseline at the beginning, and the CBV response subsequently elevated dramatically to over 30% very likely due to vasodilation. At the end of episode, CBV decreased slowly along the time. In this study, we firstly detect the vascular responses caused by KCl induced CSD with the dynamic ultrafast Doppler.",
keywords = "Cortical spreading depolarization (CSD), functional ultrasound (fUS), ultrafast Doppler",
author = "Ning Zhou and Kao, {Yu Chieh Jill} and Mei, {Yu Ying} and Lin, {Yi Pei} and Wu, {Dong Chuan} and Hsieh, {Bao Yu}",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 IEEE International Ultrasonics Symposium, IUS 2019 ; Conference date: 06-10-2019 Through 09-10-2019",
year = "2019",
month = oct,
doi = "10.1109/ULTSYM.2019.8926289",
language = "English",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
pages = "1330--1333",
booktitle = "2019 IEEE International Ultrasonics Symposium, IUS 2019",
address = "United States",
}