Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

Yu Xun Chen; Chuan Hsin Chang; Cai Wei Li; Jih Jung Chen; Tzenge Lien Shih

doi:10.1002/jccs.202300279

Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

Yu Xun Chen, Chuan Hsin Chang, Cai Wei Li, Jih Jung Chen^*, Tzenge Lien Shih^*

^*Corresponding author for this work

Faculty of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: The design and synthesis of hybrid molecules will explore finding new drugs. Objectives: The synthesized hybrid molecules to evaluate their biological properties. Methods: Apply click chemistry to tether flavonols and benzenesulfonamide. Results: Two drug candidates show potential against lung cancer. Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route.

Original language	English
Pages (from-to)	1924-1936
Number of pages	13
Journal	Journal of the Chinese Chemical Society
Volume	70
Issue number	10
DOIs	https://doi.org/10.1002/jccs.202300279
State	Published - Oct 2023

Keywords

1,2,3-triazole
benzenesulfonamide
click chemistry
flavonol
human non-small-cell lung cancer cells
hybrid molecules

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jccs.202300279

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title = "Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents",

abstract = "Background: The design and synthesis of hybrid molecules will explore finding new drugs. Objectives: The synthesized hybrid molecules to evaluate their biological properties. Methods: Apply click chemistry to tether flavonols and benzenesulfonamide. Results: Two drug candidates show potential against lung cancer. Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route.",

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author = "Chen, {Yu Xun} and Chang, {Chuan Hsin} and Li, {Cai Wei} and Chen, {Jih Jung} and Shih, {Tzenge Lien}",

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year = "2023",

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T1 - Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

AU - Chen, Yu Xun

AU - Chang, Chuan Hsin

AU - Li, Cai Wei

AU - Chen, Jih Jung

AU - Shih, Tzenge Lien

PY - 2023/10

Y1 - 2023/10

N2 - Background: The design and synthesis of hybrid molecules will explore finding new drugs. Objectives: The synthesized hybrid molecules to evaluate their biological properties. Methods: Apply click chemistry to tether flavonols and benzenesulfonamide. Results: Two drug candidates show potential against lung cancer. Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route.

AB - Background: The design and synthesis of hybrid molecules will explore finding new drugs. Objectives: The synthesized hybrid molecules to evaluate their biological properties. Methods: Apply click chemistry to tether flavonols and benzenesulfonamide. Results: Two drug candidates show potential against lung cancer. Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route.

KW - 1,2,3-triazole

KW - benzenesulfonamide

KW - click chemistry

KW - flavonol

KW - human non-small-cell lung cancer cells

KW - hybrid molecules

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U2 - 10.1002/jccs.202300279

DO - 10.1002/jccs.202300279

M3 - Article

AN - SCOPUS:85166743348

SN - 0009-4536

VL - 70

SP - 1924

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JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 10

ER -

Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

Abstract

Keywords

UN SDGs

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