Design of a Bone-Guided Cochlear Implant Microsystem with Monopolar Biphasic Multiple Stimulations and Evoked Compound Action Potential Acquisition and Its in Vivo Verification

Sung Hao Wang, Yu Kai Huang, Ching Yuan Chen, Li Yang Tang, Yen Fu Tu, Po Chih Chang, Chia Fone Lee, Chia Hsiang Yang, Chung-Chih Hung, Chien Hao Liu, Ming-Dou Ker, Chung-Yu Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A CMOS bone-guided cochlear implant (BGCI) microsystem is proposed and verified. In the implanted System on Chip (SoC) of the proposed BGCI, the evoked compound action potential (ECAP) acquisition and electrode-tissue impedance measurement (EAEIM) circuit is integrated to measure both ECAP and electrode-tissue impedance for clinical diagnoses. Both positive-/negative-voltage charge pumps and monopolar biphasic constant-current stimulation (CCS) stimulator are designed on-chip to realize monopolar biphasic CCS or double-electrode multiple stimulations with a maximum stimulation current of 1.2 mA and a step of 10 μA. With the double-electrode multiple stimulations, the electric field can be shifted and localized under the stimulating electrode to stimulate the auditory nerves. The wireless bilateral data telemetry circuits with a full-wave active rectifier and the pulsed load-shift keying (PLSK) modulators/demodulators are designed for power and data transmission. In vivo animal tests on guinea pigs have shown that the Wave III of electrically evoked auditory brainstem responses (EABRs) can be evoked successfully by electrical stimulation. Moreover, the decreasing latency gradient of evoked Wave III has been measured under the double-electrode multiple stimulations where the location of peak electric field can be shifted to the stimulating electrode in the apical site to stimulate the auditory nerves. Thus, the desired frequency resolution and spatial specificity of stimulation can be achieved. Both electrical measurement and in vivo animal tests have verified that the proposed BGCI microsystem is a feasible solution to eliminate the symptoms for patients with high-frequency hearing loss.

Original languageEnglish
Article number9460969
Pages (from-to)3062-3076
Number of pages15
JournalIEEE Journal of Solid-State Circuits
Volume56
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Bone-guided
  • cochlear implant (CI)
  • evoked compound action potential (ECAP)
  • implantable medical device (IMD)
  • in vivo animal test
  • stimulator
  • wireless power and bilateral data telemetry

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