Design and synthesis of triazolyl coumarins as Hg2+ selective fluorescent chemosensors

I. Ting Ho, Ting Ling Lai, Ren Tsung Wu, Ming Tsung Tsai, Chun Ming Wu, Gene Hsiang Lee, Wen-Sheng Chung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A series of triazolyl coumarin derivatives L1-L4, with and without spacer groups between the coumarin and the triazole groups, were synthesized as fluorescent sensors to study their binding ability and selectivity toward metal ions. Ligand L3, which contains an acetyl linker between the triazole and the coumarin, exhibited a high selectivity toward Hg2+ in polar protic solvents MeOH-CHCl3 (9 : 1, v/v) with fluorescent enhancement, furthermore, it was found to bind two Hg2+ at a high concentration (>12.5 mM) of Hg(ClO4)2. In contrast, L4, in which position 4 of the triazole unit was replaced by a benzyl group instead of the 4-tert-butylphenoxymethyl group used in L1-L3, showed a binding stoichiometry toward only one Hg2+. On the basis of the fluorescent sensing, IR, and 1H NMR titration results of ligands L1-L4, we proposed that not only the acetyl CO but also the ether group of the 4-tert-butylphenoxymethyl of L3 assisted the triazole nitrogen atoms in the complexation of Hg2+ to form a 1 : 2 complex (L3·(Hg2+)2).

Original languageEnglish
Pages (from-to)5770-5776
Number of pages7
Issue number24
StatePublished - 21 Dec 2012


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