Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su; Yu Ting Huang; Chang Shi Chen; Hao Chieh Chiu; Chung Wai Shiau

doi:10.3390/molecules23010027

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su, Yu Ting Huang, Chang Shi Chen, Hao Chieh Chiu^*, Chung Wai Shiau

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

Original language	English
Article number	27
Journal	Molecules
Volume	23
Issue number	1
DOIs	https://doi.org/10.3390/molecules23010027
State	Published - 2018

Keywords

Antibiotics
Malonamide
Staphylococcus aureus

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10.3390/molecules23010027

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abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.",

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AU - Chiu, Hao Chieh

AU - Shiau, Chung Wai

PY - 2018

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AB - Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

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KW - Malonamide

KW - Staphylococcus aureus

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Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Abstract

Keywords

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