Demonstration of EDL modulated FET biosensors with impedance analysis

Chang Run Wu; Shin Li Wang; Po Hsuan Chen; Jung Chih Chen; Yu Lin Wang

doi:10.1149/09706.0043ecst

Demonstration of EDL modulated FET biosensors with impedance analysis

Chang Run Wu, Shin Li Wang, Po Hsuan Chen, Jung Chih Chen, Yu Lin Wang

Institute of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this study, the electric double layer (EDL) modulated FET biosensor is demonstrated with impedance analysis. The unique sensor design allow protein to be detectable in high ionic strength solution. The enhanced EDL created by applying higher gate voltage is the key role to modulate the FET, causing the high sensitivity. AC impedance analysis is introduced to demonstrate the capacitance nature in our sensor system. The transduction signal of C-reactive protein (CRP) detection is dominated by imaginary part of impedance. With enhanced EDL and high transconductance of FET, this novel technology allow protein to be detectable in physiological sample without any sample pretreatment.

Original language	English
Title of host publication	237th ECS Meeting
Subtitle of host publication	Solid-State Electronics and Photonics in Biology and Medicine 7
Editors	Y.-L. Wang, W. Wu, Z.-H. Lin, A. M. Hoff, C.-T. Lin, L. F. Marsal, J. Deen, T. Sakata, Z. P. Aguilar
Publisher	IOP Publishing Ltd.
Pages	43-48
Number of pages	6
Edition	6
ISBN (Electronic)	9781607688945
DOIs	https://doi.org/10.1149/09706.0043ecst
State	Published - 1 Apr 2020
Event	237th ECS Meeting with the 18th International Meeting on Chemical Sensors, IMCS 2020 - Montreal, Canada Duration: 10 May 2020 → 14 May 2020

Publication series

Name	ECS Transactions
Number	6
Volume	97
ISSN (Print)	1938-6737
ISSN (Electronic)	1938-5862

Conference

Conference	237th ECS Meeting with the 18th International Meeting on Chemical Sensors, IMCS 2020
Country/Territory	Canada
City	Montreal
Period	10/05/20 → 14/05/20

Access to Document

10.1149/09706.0043ecst

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Wu, C. R., Wang, S. L., Chen, P. H., Chen, J. C., & Wang, Y. L. (2020). Demonstration of EDL modulated FET biosensors with impedance analysis. In Y.-L. Wang, W. Wu, Z.-H. Lin, A. M. Hoff, C.-T. Lin, L. F. Marsal, J. Deen, T. Sakata, & Z. P. Aguilar (Eds.), 237th ECS Meeting: Solid-State Electronics and Photonics in Biology and Medicine 7 (6 ed., pp. 43-48). (ECS Transactions; Vol. 97, No. 6). IOP Publishing Ltd.. https://doi.org/10.1149/09706.0043ecst

Wu, Chang Run ; Wang, Shin Li ; Chen, Po Hsuan et al. / Demonstration of EDL modulated FET biosensors with impedance analysis. 237th ECS Meeting: Solid-State Electronics and Photonics in Biology and Medicine 7. editor / Y.-L. Wang ; W. Wu ; Z.-H. Lin ; A. M. Hoff ; C.-T. Lin ; L. F. Marsal ; J. Deen ; T. Sakata ; Z. P. Aguilar. 6. ed. IOP Publishing Ltd., 2020. pp. 43-48 (ECS Transactions; 6).

@inproceedings{23c63f2b37044a63aed4529be3e321b5,

title = "Demonstration of EDL modulated FET biosensors with impedance analysis",

abstract = "In this study, the electric double layer (EDL) modulated FET biosensor is demonstrated with impedance analysis. The unique sensor design allow protein to be detectable in high ionic strength solution. The enhanced EDL created by applying higher gate voltage is the key role to modulate the FET, causing the high sensitivity. AC impedance analysis is introduced to demonstrate the capacitance nature in our sensor system. The transduction signal of C-reactive protein (CRP) detection is dominated by imaginary part of impedance. With enhanced EDL and high transconductance of FET, this novel technology allow protein to be detectable in physiological sample without any sample pretreatment.",

author = "Wu, {Chang Run} and Wang, {Shin Li} and Chen, {Po Hsuan} and Chen, {Jung Chih} and Wang, {Yu Lin}",

note = "Publisher Copyright: {\textcopyright} 2020 ECS - The Electrochemical Society.; 237th ECS Meeting with the 18th International Meeting on Chemical Sensors, IMCS 2020 ; Conference date: 10-05-2020 Through 14-05-2020",

year = "2020",

month = apr,

day = "1",

doi = "10.1149/09706.0043ecst",

language = "English",

series = "ECS Transactions",

publisher = "IOP Publishing Ltd.",

number = "6",

pages = "43--48",

editor = "Y.-L. Wang and W. Wu and Z.-H. Lin and Hoff, {A. M.} and C.-T. Lin and Marsal, {L. F.} and J. Deen and T. Sakata and Aguilar, {Z. P.}",

booktitle = "237th ECS Meeting",

address = "英國",

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}

Wu, CR, Wang, SL, Chen, PH, Chen, JC & Wang, YL 2020, Demonstration of EDL modulated FET biosensors with impedance analysis. in Y-L Wang, W Wu, Z-H Lin, AM Hoff, C-T Lin, LF Marsal, J Deen, T Sakata & ZP Aguilar (eds), 237th ECS Meeting: Solid-State Electronics and Photonics in Biology and Medicine 7. 6 edn, ECS Transactions, no. 6, vol. 97, IOP Publishing Ltd., pp. 43-48, 237th ECS Meeting with the 18th International Meeting on Chemical Sensors, IMCS 2020, Montreal, Canada, 10/05/20. https://doi.org/10.1149/09706.0043ecst

Demonstration of EDL modulated FET biosensors with impedance analysis. / Wu, Chang Run; Wang, Shin Li; Chen, Po Hsuan et al.
237th ECS Meeting: Solid-State Electronics and Photonics in Biology and Medicine 7. ed. / Y.-L. Wang; W. Wu; Z.-H. Lin; A. M. Hoff; C.-T. Lin; L. F. Marsal; J. Deen; T. Sakata; Z. P. Aguilar. 6. ed. IOP Publishing Ltd., 2020. p. 43-48 (ECS Transactions; Vol. 97, No. 6).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Demonstration of EDL modulated FET biosensors with impedance analysis

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AU - Wang, Shin Li

AU - Chen, Po Hsuan

AU - Chen, Jung Chih

AU - Wang, Yu Lin

PY - 2020/4/1

Y1 - 2020/4/1

N2 - In this study, the electric double layer (EDL) modulated FET biosensor is demonstrated with impedance analysis. The unique sensor design allow protein to be detectable in high ionic strength solution. The enhanced EDL created by applying higher gate voltage is the key role to modulate the FET, causing the high sensitivity. AC impedance analysis is introduced to demonstrate the capacitance nature in our sensor system. The transduction signal of C-reactive protein (CRP) detection is dominated by imaginary part of impedance. With enhanced EDL and high transconductance of FET, this novel technology allow protein to be detectable in physiological sample without any sample pretreatment.

AB - In this study, the electric double layer (EDL) modulated FET biosensor is demonstrated with impedance analysis. The unique sensor design allow protein to be detectable in high ionic strength solution. The enhanced EDL created by applying higher gate voltage is the key role to modulate the FET, causing the high sensitivity. AC impedance analysis is introduced to demonstrate the capacitance nature in our sensor system. The transduction signal of C-reactive protein (CRP) detection is dominated by imaginary part of impedance. With enhanced EDL and high transconductance of FET, this novel technology allow protein to be detectable in physiological sample without any sample pretreatment.

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A2 - Deen, J.

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PB - IOP Publishing Ltd.

T2 - 237th ECS Meeting with the 18th International Meeting on Chemical Sensors, IMCS 2020

Y2 - 10 May 2020 through 14 May 2020

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Wu CR, Wang SL, Chen PH, Chen JC, Wang YL. Demonstration of EDL modulated FET biosensors with impedance analysis. In Wang YL, Wu W, Lin ZH, Hoff AM, Lin CT, Marsal LF, Deen J, Sakata T, Aguilar ZP, editors, 237th ECS Meeting: Solid-State Electronics and Photonics in Biology and Medicine 7. 6 ed. IOP Publishing Ltd. 2020. p. 43-48. (ECS Transactions; 6). doi: 10.1149/09706.0043ecst

Demonstration of EDL modulated FET biosensors with impedance analysis

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