Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis

Tsung Ying Tsai, Li Wei Lo*, Shin Huei Liu, Wen Han Cheng, Yu Hui Chou, Wei Lun Lin, Yenn Jiang Lin, Shih Lin Chang, Yu Feng Hu, Fa Po Chung, Jo Nan Liao, Tze Fan Chao, Men Tzung Lo, Hui Wen Yang, Shih Ann Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

There is a delayed (lag 1 to 2 days) correlation between acute PM 2.5 (particulate matter < 2.5 μm in aerodynamic diameter) exposure and cardiovascular events, but the underlying mechanism remained unclear. We aimed to investigate the delayed impact of acute PM 2.5 exposures on cardiac autonomics through linear and nonlinear heart rate variability (HRV) analyses. Among 6912 patients who had received 24-h Holter ECG between October 1, 2015, to October 31, 2016, 56 patients (31 males, 70.3 ± 12.7 years old) were enrolled. We classified the patients as high (> 35.4 μg/m3) or low (< 35.4 μg/m3) PM 2.5 groups according to their PM 2.5 exposures on the day of Holter recordings (day 0) lag 1 and lag 2 days. Linear and nonlinear HRV parameters〔Detrended fluctuation analysis (DFA) slopes 1 and 2〕were compared. Baseline characteristics were similar between groups. Linear and nonlinear HRV parameters were similar between high- and low-exposure groups on day 0 and lag 1 day, respectively. However, DFA slope 1 was significantly lower in the high-exposure group on lag 2 days (0.784 ± 0.201 vs. 0.964 ± 0.274, p = 0.021). DFA slope 1 of the high-exposure group was significantly lower on daytime periods (9 am to 9 pm, 8 am to 4 pm and 4 pm to 12 pm) but not on nighttime periods. High lag 2 days PM 2.5 exposure is associated with low DFA slope 1 and the relationship is diurnal. This suggests that air pollution might have a delayed impact on the cardiovascular autonomic system.

Original languageEnglish
Pages (from-to)10931-10939
Number of pages9
JournalEnvironmental Science and Pollution Research
Volume28
Issue number9
DOIs
StatePublished - Mar 2021

Keywords

  • Arrhythmia
  • Autonomic
  • Delayed effect
  • Nonlinear heart rate variability
  • PM 2.5

Fingerprint

Dive into the research topics of 'Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis'. Together they form a unique fingerprint.

Cite this