Defeating antibiotic-resistant bacteria: Exploring alternative therapies for a post-antibiotic era

Chih Hung Wang, Yi Hsien Hsieh, Zachary M. Powers, Cheng Yen Kao*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


Antibiotics are one of the greatest medical advances of the 20th century, however, they are quickly becoming useless due to antibiotic resistance that has been augmented by poor antibiotic stewardship and a void in novel antibiotic discovery. Few novel classes of antibiotics have been discovered since 1960, and the pipeline of antibiotics under development is limited. We therefore are heading for a post-antibiotic era in which common infections become untreatable and once again deadly. There is thus an emergent need for both novel classes of antibiotics and novel approaches to treatment, including the repurposing of existing drugs or preclinical compounds and expanded implementation of combination therapies. In this review, we highlight to utilize alternative drug targets/therapies such as combinational therapy, anti-regulator, anti-signal transduction, anti-virulence, anti-toxin, engineered bacteriophages, and microbiome, to defeat antibiotic-resistant bacteria.

Original languageEnglish
Article number1061
JournalInternational Journal Of Molecular Sciences
Issue number3
StatePublished - 1 Feb 2020


  • Alternative therapies
  • Antibiotic resistance
  • Regulator
  • Signal transduction
  • Virulence factors


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