Deep sedation with intravenous anesthesia is associated with outcome in patients undergoing cryoablation for paroxysmal atrial fibrillation

Ting Yung Chang, Li Wei Lo*, Abigail Louise D. Te, Sugako Ishigaki, Akira Maesato, Yenn Jiang Lin, Shih Lin Chang, Yu Feng Hu, Fa Po Chung, Chin Yu Lin, Tze Fan Chao, Jo Nan Liao, Ta Chuan Tuan, Ling Kuo, Cheng I. Wu, Chih Min Liu, Ankit Jain, Isaiah C. Lugtu, Satoshi Higa, Shih Ann Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Whether deep sedation with intravenous anesthesia will affect the recurrence after cryoballoon ablation (CBA) of paroxysmal atrial fibrillation (AF) is yet to be examined. Thus, in this study, we hypothesize that there is difference in terms of the recurrence between local anesthesia and deep sedation with intravenous anesthesia after an index ablation procedure. In total, 109 patients were enrolled and received CBA, of which 68 (58.2 years) patients underwent pulmonary vein (PV) isolation with a local anesthesia (group 1) and 41 patients (63.2 years) underwent PV isolation with deep sedation using intravenous anesthesia (group 2). During the index procedure, isolation of all major PVs was achieved in 66 patients in group 1 and in 41 patients in group 2. There was no difference in non-PV triggers between the two groups. The periprocedural complication was found to be similar between the two groups (2.9% in group 1 and 4.9% in group 2). Further, 17 patients in group 1 and 4 patients in group 2 experienced recurrences after a follow-up of 19.3 months (P = 0.019). Repeat procedures revealed similar PV reconnection rates between the two groups. It has also been noted that the number of reconnected PV and incidence of atypical flutter seem to increase in group 1. Deep sedation with intravenous anesthesia during CBA for paroxysmal AF is safe and had a better long-term outcome than those with local anesthesia.

Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalInternational Heart Journal
Volume62
Issue number4
DOIs
StatePublished - Jul 2021

Keywords

  • Ablation
  • Cryoballoon
  • Deep sedation
  • Recurrence

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