Deep learning for myocardial ischemia auxiliary diagnosis using CZT SPECT myocardial perfusion imaging

Ting Yi Su, Jui Jen Chen, Wei Shiang Chen, Yen Hsiang Chang*, Henry Horng Shing Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The World Health Organization reported that cardiovascular disease is the most common cause of death worldwide. On average, one person dies of heart disease every 26 min worldwide. Deep learning approaches are characterized by the appropriate combination of abnormal features based on numerous annotated images. The constructed convolutional neural network (CNN) model can identify normal states of reversible and irreversible myocardial defects and alert physicians for further diagnosis. Methods: Cadmium zinc telluride single-photon emission computed tomography myocardial perfusion resting-state images were collected at Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan, and were analyzed with a deep learning convolutional neural network to classify myocardial perfusion images for coronary heart diseases. Results: In these grey-scale images, the heart blood flow distribution was the most crucial feature. The deep learning technique of You Only Look Once was used to determine the myocardial defect area and crop the images. After surrounding noise had been eliminated, a three-dimensional CNN model was used to identify patients with coronary heart diseases. The prediction area under the curve, accuracy, sensitivity, and specificity was 90.97, 87.08, 86.49, and 87.41%, respectively. Conclusion: Our prototype system can considerably reduce the time required for image interpretation and improve the quality of medical care. It can assist clinical experts by offering accurate coronary heart disease diagnosis in practice.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalJournal of the Chinese Medical Association
Issue number1
StatePublished - 1 Jan 2023


  • Cardiovascular diseases
  • Convolutional neural network
  • Machine learning
  • Myocardial perfusion image


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