Decreased Plasma Brain-Derived Neurotrophic Factor Levels in Institutionalized Elderly With Depressive Disorder

Chin Liang Chu, Chih Kuang Liang, Ming Yueh Chou, Yu Te Lin, Chih Chuan Pan, Ti Lu, Liang Kung Chen, Philip C. Chow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Objectives: To compare the differences in plasma brain-derived neurotrophic factor (BDNF) levels among institutionalized ethnic Chinese elderly participants with major depression, those with subclinical depression, and a nondepressed control group. Design: A cross-sectional study. Setting: The veterans' home in southern Taiwan. Participants: One hundred sixty-seven residents. Measurements: Questionnaires including the Minimum Data Set Nursing Home 2.1, Chinese-language version, and the short-form Geriatric Depression Scale, Chinese-language version. Depressive disorder was diagnosed by a well-trained psychiatrist using DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision) criteria. We measured plasma BDNF levels in the following 3 groups: nondepressive subjects (n = 122), subclinically depressive subjects (n = 33), and subjects with major depression (n = 12). Plasma BDNF was assayed using the sandwich ELISA method. Results: We noted a significantly negative association between age and plasma BDNF in the regression model. There was no significant correlation between BDNF plasma levels and body weight or platelet counts. We found that plasma BDNF was significantly lower in the major depressive group (mean, 115.1 pg/mL; SD, 57.2) than in the nondepressive group (mean, 548.8 pg/mL; SD, 370.6; P < .001). The BDNF plasma concentrations in the subclinically depressive group (mean, 231.8 pg/mL; SD, 92.4; P < .001) and control group were also significantly different. Conclusions: Our findings revealed that plasma BDNF levels were reduced not only in ethnic Chinese elderly patients with major depressive disorder but also in those with subclinical depression. This makes the plasma BDNF level a potential biological marker for clinical or subclinical depression.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalJournal of the American Medical Directors Association
Volume13
Issue number5
DOIs
StatePublished - Jun 2012

Keywords

  • Brain-derived neurotrophic factor (BDNF)
  • Major depressive disorder
  • Old age
  • Plasma
  • Subclinical depression

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