VLSI data compression research has been motivated by the needs of high-speed high-performance data compression and inspired by the VLSI technologies. An integrated data compression system has been proposed to provide adaptive multi-mode data compression for an advanced multi-instrument spacecraft payload system that has various source data. It combines a high-ratio lossy data compressor with a lossless data compressor to provide various compression schemes. The embedded lossy compressor is a high-speed neuroprocessor for adaptive vector quantization based upon a frequency-sensitive self-organization neural algorithm. The embedded lossless compressor is a high-speed pipelined processor design based on the Rice algorithm.