Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID-19

Yung Chih Wang; Yi Tzu Lee; Ting Yang; Jun Ren Sun; Ching Fen Shen; Chao Min Cheng

doi:10.1002/btm2.10177

Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID-19

Yung Chih Wang, Yi Tzu Lee, Ting Yang, Jun Ren Sun, Ching Fen Shen^*, Chao Min Cheng^*

^*Corresponding author for this work

Department of Emergency Medicine

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of COVID-19 diagnostic methods and make a case for an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insights into the current state of diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.

Original language	English
Article number	e10177
Journal	Bioengineering and Translational Medicine
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/btm2.10177
State	Published - 1 Sep 2020

Keywords

coronaviruses
COVID-19
diagnostics
point-of-care

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10.1002/btm2.10177

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abstract = "The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of COVID-19 diagnostic methods and make a case for an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insights into the current state of diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.",

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AU - Sun, Jun Ren

AU - Shen, Ching Fen

AU - Cheng, Chao Min

PY - 2020/9/1

Y1 - 2020/9/1

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AB - The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point-of-care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource-limited areas, and even in clinical settings. In this article, we summarize the current state of COVID-19 diagnostic methods and make a case for an all-in-one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID-19 infection. We believe this article will provide insights into the current state of diagnostics for COVID-19, and promote additional research and tool development that could be exceptionally impactful.

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KW - point-of-care

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Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID-19

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Keywords

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