Curiosity-driven research on acyl radicals

Ilhyong Ryu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    With a strong desire to develop radical carbonylation chemistry, we naturally focused our attention on the key reactive intermediate, the acyl radical. Acyl radicals have been regarded as nucleophilic radicals towards electron-poor alkenes, akin to vinyl radicals. However, deeming that acyl radicals may act as pseudo-carbonyl compounds, we observed acyl radicals to behave as electrophilic species, very unlike vinyl radicals. This essay is a personal account of the area of acyl radical chemistry.

    Original languageEnglish
    Pages (from-to)826-831
    Number of pages6
    JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
    Volume74
    Issue number8
    DOIs
    StatePublished - 1 Jan 2016

    Keywords

    • Acyl radical
    • Acyl radical cyclization
    • Amide
    • Amidine
    • Amine
    • Aminocarbonylation
    • Carbon monoxide
    • Dual orbital effect
    • Enyne
    • Imine
    • Lactam
    • Polarity-matched cyclization
    • [2+2+1] reaction

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