Crosstalk between hepatocyte growth factor and integrin signaling pathways

Po Chao Chan, Shu Yi Chen, Chun Hwa Chen, Hong Chen Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Most types of normal cells require integrin-mediated attachment to extracellular matrix to be able to respond to growth factor stimulation for proliferation and survival. Therefore, a consensus that integrins are close collaborators with growth factors in signal transduction has gradually emerged. Some integrins and growth factor receptors appear to be normally in relatively close proximity, which can be induced to form complexes upon cell adhesion or growth factor stimulation. Moreover, since integrins and growth factor receptors share many common elements in their signaling pathways, it is clear tzhat there are many opportunities for integrin signals to modulate growth factor signals and vice versa. Increasing evidence indicates that integrins can crosstalk with receptor tyrosine kinases in a cell- and integrin-type-dependent manner through a variety of specific mechanisms. This review is intended specifically for summarizing recent progress uncovering how the hepatocyte growth factor receptor c-Met coordinates with integrins to transmit signals.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalJournal of Biomedical Science
Issue number2
StatePublished - Mar 2006


  • Crosstalk
  • FAK
  • HGF
  • Integrin
  • Met


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