Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells

Shu Ching Chen, Chiu Chen Huang, Chung Liang Chien, Chung Jiuan Jeng, Ho Ting Su, Evelyn Chiang, Meng Ru Liu, C. H.Herbert Wu, Chung Nan Chang, Rong Hwa Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Increasing evidence has shown that death signaling in T cells is regulated in a complicated way. Molecules other than death receptors can also trigger T-cell death. Here, we demonstrate for the first time that P-selectin glycoprotein ligand-1 (PSGL-1) or CD162 molecules cross-linked by an anti-PSGL-1 monoclonal antibody, TAB4, can trigger a death signal in activated T cells. In contrast to classic cell death, PSGL-1-mediated T-cell death is caspase independent. It involves translocation of apoptosis-inducing factor from mitochondria to nucleus and mitochondrial cytochrome c release. Ultrastructurally, both peripheral condensation of chromatin and apoptotic body were observed in PSGL-1-mediated T-cell death. Collectively, this study demonstrates a novel role for PSGL-1 in controlling activated T-cell death and, thus, advances our understanding of immune regulation.

Original languageEnglish
Pages (from-to)3233-3242
Number of pages10
JournalBlood
Volume104
Issue number10
DOIs
StatePublished - 15 Nov 2004

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