Coumarin-based Hg 2+ fluorescent probe: Fluorescence turn-on detection for Hg 2+ bioimaging in living cells and zebrafish

Chong Guang Chen, Natarajan Vijay, Natesan Thirumalaivasan, Sivan Velmathi*, Shu-Pao Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The need in developing fluorescent probes for trace metal ion detection in biological samples has been an important issue. Herein, a reaction-based fluorescent probe PIC containing a perimidine moiety was designed and synthesized for Hg 2+ detection. The probe can selectively distinguish Hg 2+ with 42-fold fluorescent enhancement from the other metal ions at physiological pH. This probe can detect Hg 2+ with the detection limit of 1.08 μM. The sensor PIC can be applied to real-time detection of Hg 2+ in cells with blue emission.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume219
DOIs
StatePublished - 5 Aug 2019

Keywords

  • Bioimaging
  • Coumarin
  • Hg(II)
  • Sensor
  • Zebrafish

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