Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy

Yo Tsen Liu, Jong Ling Fuh, Jiing Feng Lirng, Anna Fen Yau Li, Donald Ming Tak Ho, Shuu Jiun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We correlated serial brain MRIs with neuropathological findings in a 16-year-old female whose autopsy was consistent with Wernicke's encephalopathy (WE). Diffusion-weighted imaging, diffusion coefficients mapping and neuropathology findings were suggested vasogenic edema in the periaqueductal and peri-the-fourth ventricular areas. This is the first documented case report to make this direct comparison. The characteristic WE changes in the mammillary body was also correlated with the findings of MRI with contrast enhancement. Bilateral cortical lesions revealed by MRI were atypical and rare in WE and were not evidenced by pathological changes.

Original languageEnglish
Pages (from-to)682-687
Number of pages6
JournalClinical Neurology and Neurosurgery
Issue number7
StatePublished - Oct 2006


  • Acute Wernicke's encephalopathy
  • Diffusion-weighted
  • Magnetic
  • Resonance imaging
  • Vasogenic edema


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