TY - JOUR
T1 - Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogeneous chinese population with normal glucose tolerance
AU - Chen, Chen Huan
AU - Tsai, Shih Tzer
AU - Chou, Pesus
N1 - Funding Information:
The authors wish to thank Ru-Ling Chen and Chan-Hwa Fan, for their laborious work in the analysis of serum insulin and C-peptide. This study was supported by grants from the National Science Council (NSC 83-0412-B-010-026 and NSC 84-2331-B-010-006), Taiwan.
PY - 1999/2/28
Y1 - 1999/2/28
N2 - We surveyed 1447 men and 1800 women aged 30 years (mean 46.7 years) with normal glucose tolerance in Kin-Chen, Kinmen. Correlations of fasting serum insulin and C-peptide with various clinical and biochemical parameters were analyzed by multiple linear regression analysis. Women had significantly higher levels of insulin than men (98±43 vs. 91±43 pM, p<0.0001), yet they also had a more favorable cardiovascular risk profile. Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Independent correlates for C-peptide were similar to those of insulin, except for the addition of mean blood pressure and the exclusion of age and total cholesterol. Significant interaction of sex-body mass index (coefficient=-0.0051, p=0.0232) was detected for C-peptide only. In conclusion, both fasting serum insulin and C-peptide are quantitatively associated with cardiovascular risk factors in this homogeneous chinese population with normal glucose tolerance. The female sex is independently associated with higher insulin and C-peptide levels, and the strength of the positive association between the female sex and C-peptide reduces when the body mass index increases.
AB - We surveyed 1447 men and 1800 women aged 30 years (mean 46.7 years) with normal glucose tolerance in Kin-Chen, Kinmen. Correlations of fasting serum insulin and C-peptide with various clinical and biochemical parameters were analyzed by multiple linear regression analysis. Women had significantly higher levels of insulin than men (98±43 vs. 91±43 pM, p<0.0001), yet they also had a more favorable cardiovascular risk profile. Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Independent correlates for C-peptide were similar to those of insulin, except for the addition of mean blood pressure and the exclusion of age and total cholesterol. Significant interaction of sex-body mass index (coefficient=-0.0051, p=0.0232) was detected for C-peptide only. In conclusion, both fasting serum insulin and C-peptide are quantitatively associated with cardiovascular risk factors in this homogeneous chinese population with normal glucose tolerance. The female sex is independently associated with higher insulin and C-peptide levels, and the strength of the positive association between the female sex and C-peptide reduces when the body mass index increases.
KW - C-peptide
KW - Epidemiology
KW - Gender difference
KW - Insulin
KW - Insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=0033611729&partnerID=8YFLogxK
U2 - 10.1016/S0167-5273(98)00366-0
DO - 10.1016/S0167-5273(98)00366-0
M3 - Article
C2 - 10189006
AN - SCOPUS:0033611729
SN - 0167-5273
VL - 68
SP - 179
EP - 186
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -