Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogeneous chinese population with normal glucose tolerance

Chen Huan Chen*, Shih Tzer Tsai, Pesus Chou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

We surveyed 1447 men and 1800 women aged 30 years (mean 46.7 years) with normal glucose tolerance in Kin-Chen, Kinmen. Correlations of fasting serum insulin and C-peptide with various clinical and biochemical parameters were analyzed by multiple linear regression analysis. Women had significantly higher levels of insulin than men (98±43 vs. 91±43 pM, p<0.0001), yet they also had a more favorable cardiovascular risk profile. Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Independent correlates for C-peptide were similar to those of insulin, except for the addition of mean blood pressure and the exclusion of age and total cholesterol. Significant interaction of sex-body mass index (coefficient=-0.0051, p=0.0232) was detected for C-peptide only. In conclusion, both fasting serum insulin and C-peptide are quantitatively associated with cardiovascular risk factors in this homogeneous chinese population with normal glucose tolerance. The female sex is independently associated with higher insulin and C-peptide levels, and the strength of the positive association between the female sex and C-peptide reduces when the body mass index increases.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalInternational Journal of Cardiology
Volume68
Issue number2
DOIs
StatePublished - 28 Feb 1999

Keywords

  • C-peptide
  • Epidemiology
  • Gender difference
  • Insulin
  • Insulin resistance

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