Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Shang Hsiu Hu; Bang Jie Liao; Chin Sheng Chiang; Po Jung Chen; I. Wei Chen; San-Yuan Chen

doi:10.1002/adma.201201251

Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Shang Hsiu Hu, Bang Jie Liao, Chin Sheng Chiang, Po Jung Chen, I. Wei Chen, San-Yuan Chen^*

^*Corresponding author for this work

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

Original language	English
Pages (from-to)	3627-3632
Number of pages	6
Journal	Advanced Materials
Volume	24
Issue number	27
DOIs	https://doi.org/10.1002/adma.201201251
State	Published - 17 Jul 2012

Keywords

double emulsions
hyperthermia
iron oxide nanoparticles
nanocapsules
synergic therapy

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10.1002/adma.201201251

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abstract = "Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.",

keywords = "double emulsions, hyperthermia, iron oxide nanoparticles, nanocapsules, synergic therapy",

author = "Hu, {Shang Hsiu} and Liao, {Bang Jie} and Chiang, {Chin Sheng} and Chen, {Po Jung} and Chen, {I. Wei} and San-Yuan Chen",

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AU - Hu, Shang Hsiu

AU - Liao, Bang Jie

AU - Chiang, Chin Sheng

AU - Chen, Po Jung

AU - Chen, I. Wei

AU - Chen, San-Yuan

PY - 2012/7/17

Y1 - 2012/7/17

N2 - Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

AB - Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

KW - double emulsions

KW - hyperthermia

KW - iron oxide nanoparticles

KW - nanocapsules

KW - synergic therapy

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U2 - 10.1002/adma.201201251

DO - 10.1002/adma.201201251

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JO - Advanced Materials

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IS - 27

ER -

Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Abstract

Keywords

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