Cone beam X-ray luminescence computed tomography reconstruction with a priori anatomical information

Pei An Lo, Meng Lung Lin, Shih Chun Jin, Jyh Cheng Chen, Syue Liang Lin, C. Allen Chang, Huihua Kenny Chiang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations


X-ray luminescence computed tomography (XLCT) is a novel molecular imaging modality that reconstructs the optical distribution of x-ray-excited phosphor particles with prior information of anatomical CT image. The prior information improves the accuracy of image reconstruction. The system can also present anatomical CT image. The optical system based on a highly sensitive charge coupled device (CCD) is perpendicular to a CT system. In the XLCT system, the x-ray was adopted to excite the phosphor of the sample and CCD camera was utilized to acquire luminescence emitted from the sample in 360-degree projections in free-space. In this study, the fluorescence diffuse optical tomography (FDOT)-like algorithm was used for image reconstruction, the structural prior information was incorporated in the reconstruction by adding a penalty term to the minimization function. The phosphor used in this study is Gd2O2S:Tb. For the simulation and experiments, the data was collected from 16 projections. The cylinder phantom was 40 mm in diameter and contains 8 mm diameter inclusion; the phosphor in the in vivo study was 5 mm in diameter at a depth of 3 mm. Both the estimation errors were no more than 5%. Based on the results from these simulation and experimental studies, the novel XLCT method has demonstrated the feasibility for in vivo animal studies.

Original languageEnglish
Title of host publicationReflection, Scattering, and Diffraction from Surfaces IV
EditorsLeonard M. Hanssen
ISBN (Electronic)9781628412321
StatePublished - 2014
EventReflection, Scattering, and Diffraction from Surfaces IV - San Diego, United States
Duration: 17 Aug 201418 Aug 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceReflection, Scattering, and Diffraction from Surfaces IV
Country/TerritoryUnited States
CitySan Diego


  • Cone beam
  • Fluorescence diffuse optical tomography
  • Hybrid imaging system
  • Image reconstruction
  • Prior anatomical information
  • X-ray luminescence computed tomography


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