Computation of brain neurodegeneration in the Alzheimer's fly

P. C. Lee*, Y. R. Huang, H. M. Chang, A. S. Chiang, Yu-Tai Ching

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Expression of human A/342 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A β 42 flies. Here, we report a three-dimensional computation algorism allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, α -shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A β. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.

Original languageEnglish
Title of host publicationMedical Imaging 2006
Subtitle of host publicationPhysiology, Function, and Structure from Medical Images
DOIs
StatePublished - 30 Jun 2006
EventMedical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: 12 Feb 200614 Feb 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6143 II
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2006: Physiology, Function, and Structure from Medical Images
Country/TerritoryUnited States
CitySan Diego, CA
Period12/02/0614/02/06

Keywords

  • α-Shape
  • Active-contour
  • Confocal microscopic images
  • Matched filter
  • Snake

Fingerprint

Dive into the research topics of 'Computation of brain neurodegeneration in the Alzheimer's fly'. Together they form a unique fingerprint.

Cite this