Comparison of efficacy of pulmonary vein isolation between cryoballoon ablation and high-power short-duration ablation

Ankit Jain, Chun Chao Chen, Shih Lin Chang*, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Fa Po Chung, Chin Yu Lin, Ting Yung Chang, Ta Chuan Tuan, Tze Fan Chao, Jo Nan Liao, Chih Min Liu, Cheng I. Wu, Chye Gen Chin, Wen Han Cheng, Shin Huei Liu, Ching Yao Chou, Isaiah C. Lugtu, Shih Ann Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: High-power short-duration (HPSD) and cryoballoon ablation (CBA) has been used for pulmonary vein isolation (PVI). Objective: We aimed to compare the efficacy of PVI between CBA and HPSD ablation in patients with paroxysmal atrial fibrillation (PAF). Methods: We retrospectively analyzed 251 consecutive PAF patients from January 2018 to July 2020. Of them, 124 patients (mean age 57.2 ± 10.1 year) received HPSD and 127 patients (mean age 59.6 ± 9.4 year) received CBA. In HPSD group, the radiofrequency energy was set as 50 W/10 s at anterior wall and 40 W/10 s at posterior wall. In CBA group, 28 mm s generation cryoballoon was used for PVI according the guidelines. Results: There was no significant difference in baseline characteristics between these 2 groups. The time to achieve PVI was significantly shorter in cryoballoon ablation group than in HPSD group (20.6 ± 1.7 min vs 51.8 ± 36.3, P = 0.001). The 6-month overall recurrence for atrial tachyarrhythmias was not significantly different between the two groups (HPSD:14.50% vs CBA:11.0%, P = 0.40). There were different types of recurrent atrial tachyarrhythmia between these 2 groups. Recurrence as atrial flutter was significantly more common in CBA group compared to HPSD group (57.1% vs 12.5%, P = 0.04). Conclusion: In PAF patients, CBA and HPSD had a favourable and comparable outcome. The recurrence pattern was different between CBA and HPSD groups.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalIndian Pacing and Electrophysiology Journal
Issue number4
StatePublished - 1 Jul 2023


  • Atrial fibrillation
  • Cryoballoon ablation
  • High power short duration ablation
  • Pulmonary vein isolation
  • Recurrence


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