Comparison of conventional and radiomic features between18 f-fbpa pet/ct and pet/mr

Chien Yi Liao, Jun Hsuang Jen, Yi Wei Chen, Chien Ying Li, Ling Wei Wang, Ren Shyan Liu, Wen Sheng Huang*, Chia Feng Lu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Boron-10-containing positron emission tomography (PET) radio-tracer,18 F-FBPA, has been used to evaluate the feasibility and treatment outcomes of Boron neutron capture therapy (BNCT). The clinical use of PET/MR is increasing and reveals its benefit in certain applications. However, the PET/CT is still the most widely used modality for daily PET practice due to its high quantitative accuracy and relatively low cost. Considering the different attenuation correction maps between PET/CT and PET/MR, comparison of derived image features from these two modalities is critical to identify quantitative imaging biomarkers for diagnosis and prognosis. This study aimed to investigate the comparability of image features extracted from18 F-FBPA PET/CT and PET/MR. A total of 15 patients with malignant brain tumor who underwent18 F-FBPA examinations using both PET/CT and PET/MR on the same day were retrospectively analyzed. Overall, four conventional imaging characteristics and 449 radiomic features were calculated from PET/CT and PET/MR, respectively. A linear regression model and intraclass correlation coefficient (ICC) were estimated to evaluate the comparability of derived features between two modalities. Features were classified into strong, moderate, and weak comparability based on coefficient of determination (r2 ) and ICC. All of the conventional features, 81.2% of histogram, 37.5% of geometry, 51.5% of texture, and 25% of wavelet-based features, showed strong comparability between PET/CT and PET/MR. With regard to the wavelet filtering, radiomic features without filtering (61.2%) or with low-pass filtering (59.2%) along three axes produced strong comparability between the two modalities. However, only 8.2% of the features with high-pass filtering showed strong comparability. The linear regression models were provided for the features with strong and moderate consensus to interchange the quantitative features between the PET/CT and the PET/MR. All of the conventional and 71% of the radiomic (mostly histogram and texture) features were sufficiently stable and could be interchanged between18 F-FBPA PET with different hybrid modalities using the proposed equations. Our findings suggested that the image features high interchangeability may facilitate future studies in comparing PET/CT and PET/MR.

Original languageEnglish
Article number1659
Issue number11
StatePublished - Nov 2021


  • F-FBPA
  • Boron neutron capture therapy (BNCT)
  • Malignant tumor
  • Nuclear medicine
  • PET/CT
  • PET/MR
  • Positron emission tomography
  • Radiomics
  • T/N ratio


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