TY - JOUR
T1 - Compare fuhrman nuclear and chromophobe tumor grade on chromophobe RCC
AU - Lin, Tsu Feng
AU - Lin, Wun Rong
AU - Chen, Marcelo
AU - Dai, Shuen Han
AU - Sun, Fang Ju
AU - Tsai, Wei Kung
AU - Chiu, Allen W.
N1 - Publisher Copyright:
© 2019 2019 Tsu-Feng Lin et al. published by De Gruyter.
PY - 2019
Y1 - 2019
N2 - Chromophobe renal cell carcinoma (chRCC) has a favorable prognosis. Due to irregular nuclei and nuclear pleomorphism, chRCC has a high Fuhrman nuclear grade (FNG). The chromophobe tumor grade (CTG) is a novel three-Tier grading system that has been reported to be a better prognosticator than the traditional FNG. We compared the two nuclear grading systems in terms of patients' clinical outcomes. We performed this retrospective chart review of all patients with chRCC from 2000 to 2017. All pathologic features and CTG and FNG results were re-evaluated. Eighteen patients' records were reviewed with a mean follow-up of 70.6 months. The nuclear grading distribution was as follows: FNG 2, 56%; FNG 3, 39%; FNG 4, 5%; CTG 1, 78%; CTG 2, 17%; and CTG 3, 6%. Only one patient died. This patient had adrenal invasion, lung metastasis, sarcomatoid change and tumor necrosis, and the tumor was graded as FNG 4 and CTG 3. Overall survival was associated with both FNG and CTG. Chromophobe RCC was associated with a low rate of cancer-specific death and sarcomatoid differentiation. Both FNG and CTG were associated with overall survival.
AB - Chromophobe renal cell carcinoma (chRCC) has a favorable prognosis. Due to irregular nuclei and nuclear pleomorphism, chRCC has a high Fuhrman nuclear grade (FNG). The chromophobe tumor grade (CTG) is a novel three-Tier grading system that has been reported to be a better prognosticator than the traditional FNG. We compared the two nuclear grading systems in terms of patients' clinical outcomes. We performed this retrospective chart review of all patients with chRCC from 2000 to 2017. All pathologic features and CTG and FNG results were re-evaluated. Eighteen patients' records were reviewed with a mean follow-up of 70.6 months. The nuclear grading distribution was as follows: FNG 2, 56%; FNG 3, 39%; FNG 4, 5%; CTG 1, 78%; CTG 2, 17%; and CTG 3, 6%. Only one patient died. This patient had adrenal invasion, lung metastasis, sarcomatoid change and tumor necrosis, and the tumor was graded as FNG 4 and CTG 3. Overall survival was associated with both FNG and CTG. Chromophobe RCC was associated with a low rate of cancer-specific death and sarcomatoid differentiation. Both FNG and CTG were associated with overall survival.
KW - Chromophobe renal cell carcinoma
KW - Chromophobe tumor grade
KW - Fuhrman nuclear grade
KW - Nuclear grading system
UR - http://www.scopus.com/inward/record.url?scp=85064967042&partnerID=8YFLogxK
U2 - 10.1515/med-2019-0032
DO - 10.1515/med-2019-0032
M3 - Article
AN - SCOPUS:85064967042
SN - 2391-5463
VL - 14
SP - 336
EP - 342
JO - Open Medicine (Poland)
JF - Open Medicine (Poland)
IS - 1
ER -
