Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

Ping Hisen Chen, Chien Hsien Wu, Yi Fen Chen, Yi Chen Yeh, Bo Han Lin, Kuo Wei Chang, Pei Yu Lai, Ming Chih Hou, Ching Liang Lu, Wen Chuan Kuo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4-nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.

Original languageEnglish
Article number#320308
Pages (from-to)1461-1476
Number of pages16
JournalBiomedical Optics Express
Volume9
Issue number4
DOIs
StatePublished - 1 Apr 2018

Fingerprint

Dive into the research topics of 'Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages'. Together they form a unique fingerprint.

Cite this