Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

Ping Hisen Chen; Chien Hsien Wu; Yi Fen Chen; Yi Chen Yeh; Bo Han Lin; Kuo Wei Chang; Pei Yu Lai; Ming Chih Hou; Ching Liang Lu; Wen Chuan Kuo

doi:10.1364/BOE.9.001461

Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

Ping Hisen Chen, Chien Hsien Wu, Yi Fen Chen, Yi Chen Yeh, Bo Han Lin, Kuo Wei Chang, Pei Yu Lai, Ming Chih Hou, Ching Liang Lu, Wen Chuan Kuo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4-nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.

Original language	English
Article number	#320308
Pages (from-to)	1461-1476
Number of pages	16
Journal	Biomedical Optics Express
Volume	9
Issue number	4
DOIs	https://doi.org/10.1364/BOE.9.001461
State	Published - 1 Apr 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1364/BOE.9.001461

Cite this

Chen, P. H., Wu, C. H., Chen, Y. F., Yeh, Y. C., Lin, B. H., Chang, K. W., Lai, P. Y., Hou, M. C., Lu, C. L., & Kuo, W. C. (2018). Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages. Biomedical Optics Express, 9(4), 1461-1476. Article #320308. https://doi.org/10.1364/BOE.9.001461

@article{95122bf4c75243c4a188f13586c060bd,

title = "Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages",

abstract = "Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4-nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.",

author = "Chen, {Ping Hisen} and Wu, {Chien Hsien} and Chen, {Yi Fen} and Yeh, {Yi Chen} and Lin, {Bo Han} and Chang, {Kuo Wei} and Lai, {Pei Yu} and Hou, {Ming Chih} and Lu, {Ching Liang} and Kuo, {Wen Chuan}",

note = "Publisher Copyright: {\textcopyright} 2018 Optical Society of America.",

year = "2018",

month = apr,

day = "1",

doi = "10.1364/BOE.9.001461",

language = "English",

volume = "9",

pages = "1461--1476",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "Optica Publishing Group (formerly OSA)",

number = "4",

}

TY - JOUR

T1 - Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

AU - Chen, Ping Hisen

AU - Wu, Chien Hsien

AU - Chen, Yi Fen

AU - Yeh, Yi Chen

AU - Lin, Bo Han

AU - Chang, Kuo Wei

AU - Lai, Pei Yu

AU - Hou, Ming Chih

AU - Lu, Ching Liang

AU - Kuo, Wen Chuan

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4-nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.

AB - Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4-nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.

UR - http://www.scopus.com/inward/record.url?scp=85044967989&partnerID=8YFLogxK

U2 - 10.1364/BOE.9.001461

DO - 10.1364/BOE.9.001461

M3 - Article

AN - SCOPUS:85044967989

SN - 2156-7085

VL - 9

SP - 1461

EP - 1476

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 4

M1 - #320308

ER -

Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this