TY - JOUR
T1 - Colorectal carcinoma
T2 - From tumorigenesis to treatment
AU - Wang, W. S.
AU - Chen, P. M.
AU - Su, Y.
PY - 2006/3
Y1 - 2006/3
N2 - Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin β-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.
AB - Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin β-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.
KW - Colorectal carcinoma
KW - Hedgehog
KW - Matrix metalloproteinase
KW - Staging
KW - Stem cells
KW - Thymosin β-4
KW - Treatment
KW - Tumorigenesis
UR - http://www.scopus.com/inward/record.url?scp=33645090180&partnerID=8YFLogxK
U2 - 10.1007/s00018-005-5425-4
DO - 10.1007/s00018-005-5425-4
M3 - Review article
C2 - 16501890
AN - SCOPUS:33645090180
SN - 1420-682X
VL - 63
SP - 663
EP - 671
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 6
ER -
