Clinicopathological and molecular features of patients with early and late recurrence after curative surgery for colorectal cancer

Yuan Tzu Lan*, Shih Ching Chang, Pei Ching Lin, Chun Chi Lin, Hung Hsin Lin, Sheng Chieh Huang, Chien Hsing Lin, Wen Yi Liang, Wei Shone Chen, Jeng Kai Jiang, Shung Haur Yang, Jen Kou Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Few reports have investigated genetic alterations between patients with early and late recurrence following curative surgery for colorectal cancer (CRC). Methods: A total of 1227 stage I–III CRC patients who underwent curative resection were included retrospectively. Among them, 236 patients had tumor recurrence: 139 had early (<2 years after surgery) and 97 had late (≥2 years after surgery) recurrence. Clinicopathological features and genetic alterations were compared between the two groups. Results: Compared to those with late recurrence, patients with early recurrence were more likely to have advanced pathological node (N) categories; tumor, node, metastasis (TNM) stages; adjuvant chemotherapy treatment; liver metastases; APC mutations; and worse five-year overall survival rates. Patients with right-sided colon cancer were more likely to develop early recurrence than were those with left-sided colon cancer or rectal cancer. Regarding rectal cancer, patients with early recurrence were more likely to be at advanced pathological N categories and TNM stages than those with late recurrence. Multivariate analysis revealed old age, early recurrence, multiple-site recurrence, and BRAF and NRAS mutations to be independent prognostic factors. Conclusion: CRC patients with early recurrence have a worse OS rate and more APC mutations than those with late recurrence.

Original languageEnglish
Article number1883
JournalCancers
Volume13
Issue number8
DOIs
StatePublished - 2 Apr 2021

Keywords

  • Colorectal cancer
  • Early recurrence
  • Genetic alteration
  • Late recurrence
  • Prognostic factor

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