Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Chun Chi Lin; Yi Ling Lai; Tzu Chen Lin; Wei Shone Chen; Jeng Kai Jiang; Shung Haur Yang; Huann Sheng Wang; Yuan Tzu Lan; Wen Yih Liang; Hui Mei Hsu; Jen Kou Lin; Shih Ching Chang

doi:10.1007/s00384-011-1341-2

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Chun Chi Lin, Yi Ling Lai, Tzu Chen Lin, Wei Shone Chen, Jeng Kai Jiang, Shung Haur Yang, Huann Sheng Wang, Yuan Tzu Lan, Wen Yih Liang, Hui Mei Hsu, Jen Kou Lin, Shih Ching Chang^*

^*Corresponding author for this work

Department of Surgery

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

Original language	English
Pages (from-to)	277-286
Number of pages	10
Journal	International Journal of Colorectal Disease
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s00384-011-1341-2
State	Published - Mar 2012

Keywords

Colon cancer
MSI
Microsatellite
Mismatch repair
Prognosis
Replication error

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00384-011-1341-2

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@article{b225af4c647446cbae590bc9ae184226,

title = "Clinicopathologic features and prognostic analysis of MSI-high colon cancer",

abstract = "Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.",

keywords = "Colon cancer, MSI, Microsatellite, Mismatch repair, Prognosis, Replication error",

author = "Lin, {Chun Chi} and Lai, {Yi Ling} and Lin, {Tzu Chen} and Chen, {Wei Shone} and Jiang, {Jeng Kai} and Yang, {Shung Haur} and Wang, {Huann Sheng} and Lan, {Yuan Tzu} and Liang, {Wen Yih} and Hsu, {Hui Mei} and Lin, {Jen Kou} and Chang, {Shih Ching}",

note = "Funding Information: Acknowledgments We thank the Cancer Registry of Cancer Center, Taipei Veterans General Hospital for providing part of patient follow-up information. The research was supported by Taipei Veterans General Hospital: V100E2-008 and National Science Council 97-2314-B-075-051-MY3",

year = "2012",

month = mar,

doi = "10.1007/s00384-011-1341-2",

language = "English",

volume = "27",

pages = "277--286",

journal = "International Journal of Colorectal Disease",

issn = "0179-1958",

publisher = "Springer Nature",

number = "3",

}

TY - JOUR

T1 - Clinicopathologic features and prognostic analysis of MSI-high colon cancer

AU - Lin, Chun Chi

AU - Lai, Yi Ling

AU - Lin, Tzu Chen

AU - Chen, Wei Shone

AU - Jiang, Jeng Kai

AU - Yang, Shung Haur

AU - Wang, Huann Sheng

AU - Lan, Yuan Tzu

AU - Liang, Wen Yih

AU - Hsu, Hui Mei

AU - Lin, Jen Kou

AU - Chang, Shih Ching

N1 - Funding Information: Acknowledgments We thank the Cancer Registry of Cancer Center, Taipei Veterans General Hospital for providing part of patient follow-up information. The research was supported by Taipei Veterans General Hospital: V100E2-008 and National Science Council 97-2314-B-075-051-MY3

PY - 2012/3

Y1 - 2012/3

N2 - Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

AB - Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

KW - Colon cancer

KW - MSI

KW - Microsatellite

KW - Mismatch repair

KW - Prognosis

KW - Replication error

UR - http://www.scopus.com/inward/record.url?scp=84861986852&partnerID=8YFLogxK

U2 - 10.1007/s00384-011-1341-2

DO - 10.1007/s00384-011-1341-2

M3 - Article

C2 - 22076610

AN - SCOPUS:84861986852

SN - 0179-1958

VL - 27

SP - 277

EP - 286

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

IS - 3

ER -

Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Abstract

Keywords

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