Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Chun Chi Lin, Yi Ling Lai, Tzu Chen Lin, Wei Shone Chen, Jeng Kai Jiang, Shung Haur Yang, Huann Sheng Wang, Yuan Tzu Lan, Wen Yih Liang, Hui Mei Hsu, Jen Kou Lin, Shih Ching Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalInternational Journal of Colorectal Disease
Issue number3
StatePublished - Mar 2012


  • Colon cancer
  • Microsatellite
  • Mismatch repair
  • MSI
  • Prognosis
  • Replication error


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