Clinical significance of serum hepatitis C virus titers in patients with chronic type C hepatitis

Jia Horng Kao, Ming Yang Lai, Pei Jer Chen, Lih Hwa Hwang, Wendy Chen, Ding Shinn Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Objectives: To investigate the relationship between serum hepatitis C virus (HCV) titers and clinicopathological characteristics of chronic type C hepatitis. Methods: Serum HCV cDNA concentrations were determined by a competitive polymerase chain reaction assay in 60 Taiwanese patients with chronic type C hepatitis. Results: The concentration of serum HCV cDNA ranged between 102 and 108 copies/mL. The titers of serum HCV (logarithmic transformed copies of HCV cDNA/mL serum) were not significantly correlated with clinicopathological characteristics with respect to either sex of the patients, source of infection, higher serum ALT level (> 150 IU/L) or histological severity. In contrast, serum HCV titers were significantly higher in patients with age above 50 yr and with type lb HCV infection. Moreover, the influence of advancing age on serum HCV titer was genotype- independent by multivariate analysis. Conclusions: These results suggest that advancing age and genotype are both important determinants of HCV viremia and that the pathogenesis of HCV infection might not be caused by direct cytotoxicity of the virus.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number3
StatePublished - Mar 1996


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