Clinical significance of p16INK4A and p53 overexpression in endocrine tumors of the gastrointestinal tract

Anna Fen Yau Li*, Shyh Haw Tsay, Wen Yih Liang, Wing Yin Li, Jeou Yuan Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This study was designed to determine the expression of p16, p53, and CD117 in gastrointestinal tract endocrine tumors. Immunohistochemical studies of p16, p53, and CD117 were performed in 57 gastrointestinal tract endocrine tumors, including 22 poorly differentiated endocrine carcinomas (PDECs) and 35 well-differentiated endocrine tumors (WDETs). Overexpression of p16 and p53 was observed in 16 (73%) and 10 (45%) of the PDECs, respectively, whereas only 1 WDET showed overexpression of p53 and none showed overexpression of p16. A total of 18 (82%) of the PDECs showed overexpression of p16 or p53 proteins. This is closely associated with PDEC (P < .0001). By using overexpression of p16 or p53 as the criteria for PDEC, the sensitivity and specificity are 81.8% and 97.1%, respectively, with positive and negative predictive values of 94.7% and 89.5%, respectively. CD117 was not detected in any of the 57 gastrointestinal endocrine tumors by immunohistochemical analysis.

Original languageEnglish
Pages (from-to)856-865
Number of pages10
JournalAmerican Journal of Clinical Pathology
Volume126
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • CD117
  • Gastrointestinal tract
  • Neuroendocrine tumors
  • p16
  • p53

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