TY - JOUR
T1 - Clinical significance of p16INK4A and p53 overexpression in endocrine tumors of the gastrointestinal tract
AU - Li, Anna Fen Yau
AU - Tsay, Shyh Haw
AU - Liang, Wen Yih
AU - Li, Wing Yin
AU - Chen, Jeou Yuan
PY - 2006/12
Y1 - 2006/12
N2 - This study was designed to determine the expression of p16, p53, and CD117 in gastrointestinal tract endocrine tumors. Immunohistochemical studies of p16, p53, and CD117 were performed in 57 gastrointestinal tract endocrine tumors, including 22 poorly differentiated endocrine carcinomas (PDECs) and 35 well-differentiated endocrine tumors (WDETs). Overexpression of p16 and p53 was observed in 16 (73%) and 10 (45%) of the PDECs, respectively, whereas only 1 WDET showed overexpression of p53 and none showed overexpression of p16. A total of 18 (82%) of the PDECs showed overexpression of p16 or p53 proteins. This is closely associated with PDEC (P < .0001). By using overexpression of p16 or p53 as the criteria for PDEC, the sensitivity and specificity are 81.8% and 97.1%, respectively, with positive and negative predictive values of 94.7% and 89.5%, respectively. CD117 was not detected in any of the 57 gastrointestinal endocrine tumors by immunohistochemical analysis.
AB - This study was designed to determine the expression of p16, p53, and CD117 in gastrointestinal tract endocrine tumors. Immunohistochemical studies of p16, p53, and CD117 were performed in 57 gastrointestinal tract endocrine tumors, including 22 poorly differentiated endocrine carcinomas (PDECs) and 35 well-differentiated endocrine tumors (WDETs). Overexpression of p16 and p53 was observed in 16 (73%) and 10 (45%) of the PDECs, respectively, whereas only 1 WDET showed overexpression of p53 and none showed overexpression of p16. A total of 18 (82%) of the PDECs showed overexpression of p16 or p53 proteins. This is closely associated with PDEC (P < .0001). By using overexpression of p16 or p53 as the criteria for PDEC, the sensitivity and specificity are 81.8% and 97.1%, respectively, with positive and negative predictive values of 94.7% and 89.5%, respectively. CD117 was not detected in any of the 57 gastrointestinal endocrine tumors by immunohistochemical analysis.
KW - CD117
KW - Gastrointestinal tract
KW - Neuroendocrine tumors
KW - p16
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=85047696807&partnerID=8YFLogxK
U2 - 10.1309/5X6WBYJ3U94EEKNN
DO - 10.1309/5X6WBYJ3U94EEKNN
M3 - Article
C2 - 17074692
AN - SCOPUS:85047696807
SN - 0002-9173
VL - 126
SP - 856
EP - 865
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 6
ER -