Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database

Hsueh Ju Lu; Meng Che Hsieh; Hung Ming Wang; Jason Chia Hsun Hsieh; Chia Jui Yen; Shang Yin Wu; Huai Cheng Huang; Hui Ching Wang; Pen Yuan Chu; Tien Hua Chen; Chih Yen Chien; Tai Lin Huang; Yi Fang Chang; Chun Hung Hua; Ming Yu Lien; Jo Pai Chen; Wei Chen Lu; Jin Ching Lin; Chen Chi Wang; Yi Chun Liu; Muh Hwa Yang; Pei Jen Lou

doi:10.1002/hed.27681

Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database

Hsueh Ju Lu, Meng Che Hsieh, Hung Ming Wang, Jason Chia Hsun Hsieh, Chia Jui Yen, Shang Yin Wu, Huai Cheng Huang, Hui Ching Wang, Pen Yuan Chu, Tien Hua Chen, Chih Yen Chien, Tai Lin Huang, Yi Fang Chang, Chun Hung Hua, Ming Yu Lien, Jo Pai Chen, Wei Chen Lu, Jin Ching Lin, Chen Chi Wang, Yi Chun LiuMuh Hwa Yang^*, Pei Jen Lou

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: For R/M HNSCC, the differences in prognosis and treatment options between distant metastasis (DM) and locoregional recurrence, especially in the DM group, remain unclear. Methods: From the Taiwan Head Neck Society registry database, patients who were diagnosed with R/M HNSCC and received cetuximab-based frontline therapy were collected for analysis. Results: Among the enrolled patients, 59.3% (491/827) belonged to the DM group. The DM group had less primary site of oral cavity, less betel nut chewing, higher lactate dehydrogenase (LDH) levels, and higher LDH/albumin ratio compared with the non-DM group. For the patients with primary site of oral cavity and current smokers, DM coexisted with poorer outcomes. In the DM group, EXTREME-like regimen was more suitable for older patients, those with elevated LDH, and those with higher LDH/albumin ratio than TPExtreme-like regimen. Conclusion: DM coexisted with poorer prognosis in certain groups. LDH-associated biomarkers may aid treatment options for DM patients.

Original language	English
Pages (from-to)	1063-1073
Number of pages	11
Journal	Head and Neck
Volume	46
Issue number	5
DOIs	https://doi.org/10.1002/hed.27681
State	Published - May 2024

Keywords

biomarkers
cetuximab
distant metastasis
head and neck squamous cell carcinoma
lactate dehydrogenase

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10.1002/hed.27681

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Lu, H. J., Hsieh, M. C., Wang, H. M., Hsieh, J. C. H., Yen, C. J., Wu, S. Y., Huang, H. C., Wang, H. C., Chu, P. Y., Chen, T. H., Chien, C. Y., Huang, T. L., Chang, Y. F., Hua, C. H., Lien, M. Y., Chen, J. P., Lu, W. C., Lin, J. C., Wang, C. C., ... Lou, P. J. (2024). Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database. Head and Neck, 46(5), 1063-1073. https://doi.org/10.1002/hed.27681

@article{2c5d9184a5914d5f899ad9b280763ade,

title = "Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database",

abstract = "Background: For R/M HNSCC, the differences in prognosis and treatment options between distant metastasis (DM) and locoregional recurrence, especially in the DM group, remain unclear. Methods: From the Taiwan Head Neck Society registry database, patients who were diagnosed with R/M HNSCC and received cetuximab-based frontline therapy were collected for analysis. Results: Among the enrolled patients, 59.3% (491/827) belonged to the DM group. The DM group had less primary site of oral cavity, less betel nut chewing, higher lactate dehydrogenase (LDH) levels, and higher LDH/albumin ratio compared with the non-DM group. For the patients with primary site of oral cavity and current smokers, DM coexisted with poorer outcomes. In the DM group, EXTREME-like regimen was more suitable for older patients, those with elevated LDH, and those with higher LDH/albumin ratio than TPExtreme-like regimen. Conclusion: DM coexisted with poorer prognosis in certain groups. LDH-associated biomarkers may aid treatment options for DM patients.",

keywords = "biomarkers, cetuximab, distant metastasis, head and neck squamous cell carcinoma, lactate dehydrogenase",

author = "Lu, {Hsueh Ju} and Hsieh, {Meng Che} and Wang, {Hung Ming} and Hsieh, {Jason Chia Hsun} and Yen, {Chia Jui} and Wu, {Shang Yin} and Huang, {Huai Cheng} and Wang, {Hui Ching} and Chu, {Pen Yuan} and Chen, {Tien Hua} and Chien, {Chih Yen} and Huang, {Tai Lin} and Chang, {Yi Fang} and Hua, {Chun Hung} and Lien, {Ming Yu} and Chen, {Jo Pai} and Lu, {Wei Chen} and Lin, {Jin Ching} and Wang, {Chen Chi} and Liu, {Yi Chun} and Yang, {Muh Hwa} and Lou, {Pei Jen}",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley Periodicals LLC.",

year = "2024",

month = may,

doi = "10.1002/hed.27681",

language = "English",

volume = "46",

pages = "1063--1073",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "5",

}

Lu, HJ, Hsieh, MC, Wang, HM, Hsieh, JCH, Yen, CJ, Wu, SY, Huang, HC, Wang, HC, Chu, PY, Chen, TH, Chien, CY, Huang, TL, Chang, YF, Hua, CH, Lien, MY, Chen, JP, Lu, WC, Lin, JC, Wang, CC, Liu, YC, Yang, MH & Lou, PJ 2024, 'Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database', Head and Neck, vol. 46, no. 5, pp. 1063-1073. https://doi.org/10.1002/hed.27681

TY - JOUR

T1 - Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma

T2 - A real-world study using Taiwan Head Neck Society registry database

AU - Lu, Hsueh Ju

AU - Hsieh, Meng Che

AU - Wang, Hung Ming

AU - Hsieh, Jason Chia Hsun

AU - Yen, Chia Jui

AU - Wu, Shang Yin

AU - Huang, Huai Cheng

AU - Wang, Hui Ching

AU - Chu, Pen Yuan

AU - Chen, Tien Hua

AU - Chien, Chih Yen

AU - Huang, Tai Lin

AU - Chang, Yi Fang

AU - Hua, Chun Hung

AU - Lien, Ming Yu

AU - Chen, Jo Pai

AU - Lu, Wei Chen

AU - Lin, Jin Ching

AU - Wang, Chen Chi

AU - Liu, Yi Chun

AU - Yang, Muh Hwa

AU - Lou, Pei Jen

PY - 2024/5

Y1 - 2024/5

N2 - Background: For R/M HNSCC, the differences in prognosis and treatment options between distant metastasis (DM) and locoregional recurrence, especially in the DM group, remain unclear. Methods: From the Taiwan Head Neck Society registry database, patients who were diagnosed with R/M HNSCC and received cetuximab-based frontline therapy were collected for analysis. Results: Among the enrolled patients, 59.3% (491/827) belonged to the DM group. The DM group had less primary site of oral cavity, less betel nut chewing, higher lactate dehydrogenase (LDH) levels, and higher LDH/albumin ratio compared with the non-DM group. For the patients with primary site of oral cavity and current smokers, DM coexisted with poorer outcomes. In the DM group, EXTREME-like regimen was more suitable for older patients, those with elevated LDH, and those with higher LDH/albumin ratio than TPExtreme-like regimen. Conclusion: DM coexisted with poorer prognosis in certain groups. LDH-associated biomarkers may aid treatment options for DM patients.

AB - Background: For R/M HNSCC, the differences in prognosis and treatment options between distant metastasis (DM) and locoregional recurrence, especially in the DM group, remain unclear. Methods: From the Taiwan Head Neck Society registry database, patients who were diagnosed with R/M HNSCC and received cetuximab-based frontline therapy were collected for analysis. Results: Among the enrolled patients, 59.3% (491/827) belonged to the DM group. The DM group had less primary site of oral cavity, less betel nut chewing, higher lactate dehydrogenase (LDH) levels, and higher LDH/albumin ratio compared with the non-DM group. For the patients with primary site of oral cavity and current smokers, DM coexisted with poorer outcomes. In the DM group, EXTREME-like regimen was more suitable for older patients, those with elevated LDH, and those with higher LDH/albumin ratio than TPExtreme-like regimen. Conclusion: DM coexisted with poorer prognosis in certain groups. LDH-associated biomarkers may aid treatment options for DM patients.

KW - biomarkers

KW - cetuximab

KW - distant metastasis

KW - head and neck squamous cell carcinoma

KW - lactate dehydrogenase

UR - http://www.scopus.com/inward/record.url?scp=85186400560&partnerID=8YFLogxK

U2 - 10.1002/hed.27681

DO - 10.1002/hed.27681

M3 - Article

C2 - 38385970

AN - SCOPUS:85186400560

SN - 1043-3074

VL - 46

SP - 1063

EP - 1073

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -

Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database

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Keywords

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