Clinical outcome of local treatment and radical resection for pT1 rectal cancer

Summer Sheue Tsuey Pai, Hung Hsin Lin*, Hou Hsuan Cheng, Sheng Chieh Huang, Chun Chi Lin, Yuan Tzu Lan, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Wei-Shone Chen, Jen Kou Lin, Shih-Ching Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Rectal cancer is mainly cured by radical resection with neoadjuvant chemoradiation or adjuvant chemotherapy. Pathological T1 lesions can be managed by local treatment and radiotherapy thereafter. Lower morbidity is the key benefit of these local treatments. Since nodal metastasis is important for staging, radical resection (RR) is suggested. Rectal cancer has higher surgical morbidity than colon cancer; local treatment has been the preferred choice by patients. Methods: We retrospectively enrolled data of 244 patients with pT1 rectal adenocarcinoma. A total of 202 patients (82.8%) underwent RR, including low anterior resection (LAR) and abdomino-perineal resection (APR), and 42 patients (17.2%) underwent LT, including transanal excision and colonoscopic polypectomy. Results: In our study, seven patients (16.7%) had loco-regional recurrence and distant metastasis from the LT group while eight patients (4.0%) had distant metastasis without loco-regional recurrence from the RR group. The lymph node metastasis rate in RR group was 8.4%. Forty-seven patients (24.2%) underwent LAR with temporary stoma, and its reversal rate was 100%. In the RR group, postoperative complication rate was 10.4% with a mortality rate of 0.5%. Recurrence-free survival (RFS) was 95.7% for RR and 80.2% for LT (P = 0.001), and overall survival (OS) was 93.7% for RR and 70.0% for LT (P = 0.001). Conclusion: This study found that RFS and OS in patients of pT1 rectal adenocarcinoma that had received RR were better than receiving LT. Further adjuvant chemotherapy was possible for some RR patients. A higher recurrence rate after LT must be balanced against the morbidity and mortality associated with RR.

Original languageEnglish
JournalInternational Journal of Colorectal Disease
StateAccepted/In press - 2022


  • Clinical outcome
  • Early stage
  • Local treatment
  • pT1
  • Radical resection
  • Rectal cancer


Dive into the research topics of 'Clinical outcome of local treatment and radical resection for pT1 rectal cancer'. Together they form a unique fingerprint.

Cite this