Clinical and molecular analyses of castleman's disease

Po Min Chen; Chin Chen Pan; Chiau Jun Chu; Jin Hwang Liu

Clinical and molecular analyses of castleman's disease

Po Min Chen^*, Chin Chen Pan, Chiau Jun Chu, Jin Hwang Liu

^*Corresponding author for this work

Institute of Biopharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Castleman's disease is a morphologically and clinically heterogeneous lyrnphoproliferative disorder. Both hyaline vascular (HV) and plasma cell (PC) type were described. Systemic multicentric manifestation with a higher risk to develop malignant lymphoma was known in the latter type. Formaline-fixed, paraffin-embedded tissue from 15 Castleman's diseases were analyzed for clonal irnrnunoglobulin heavy chain rearrangement {IHR; by a semi-nest polymerase chain reaction (PCR) to amplify the complementary determining region III. As a sensitivity control, 92% of IHR detected by Southern blot analysis in malignant lymphoma was PCR positive. However, neither the HV (7 cases) or the PC (8 cases) type of and neither localized (7HVs and 2PCs) or multicentric (6PCs) Castleman's disease showed monoclonality. Clonality analysis in Castleman's disease thus seemed to be ineffective in predicting the disease behaviors.

Original language	English
Pages (from-to)	792
Number of pages	1
Journal	Experimental Hematology
Volume	26
Issue number	8
State	Published - 1998

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title = "Clinical and molecular analyses of castleman's disease",

abstract = "Castleman's disease is a morphologically and clinically heterogeneous lyrnphoproliferative disorder. Both hyaline vascular (HV) and plasma cell (PC) type were described. Systemic multicentric manifestation with a higher risk to develop malignant lymphoma was known in the latter type. Formaline-fixed, paraffin-embedded tissue from 15 Castleman's diseases were analyzed for clonal irnrnunoglobulin heavy chain rearrangement {IHR; by a semi-nest polymerase chain reaction (PCR) to amplify the complementary determining region III. As a sensitivity control, 92% of IHR detected by Southern blot analysis in malignant lymphoma was PCR positive. However, neither the HV (7 cases) or the PC (8 cases) type of and neither localized (7HVs and 2PCs) or multicentric (6PCs) Castleman's disease showed monoclonality. Clonality analysis in Castleman's disease thus seemed to be ineffective in predicting the disease behaviors.",

author = "Chen, {Po Min} and Pan, {Chin Chen} and Chu, {Chiau Jun} and Liu, {Jin Hwang}",

year = "1998",

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journal = "Experimental Hematology",

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AU - Chen, Po Min

AU - Pan, Chin Chen

AU - Chu, Chiau Jun

AU - Liu, Jin Hwang

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N2 - Castleman's disease is a morphologically and clinically heterogeneous lyrnphoproliferative disorder. Both hyaline vascular (HV) and plasma cell (PC) type were described. Systemic multicentric manifestation with a higher risk to develop malignant lymphoma was known in the latter type. Formaline-fixed, paraffin-embedded tissue from 15 Castleman's diseases were analyzed for clonal irnrnunoglobulin heavy chain rearrangement {IHR; by a semi-nest polymerase chain reaction (PCR) to amplify the complementary determining region III. As a sensitivity control, 92% of IHR detected by Southern blot analysis in malignant lymphoma was PCR positive. However, neither the HV (7 cases) or the PC (8 cases) type of and neither localized (7HVs and 2PCs) or multicentric (6PCs) Castleman's disease showed monoclonality. Clonality analysis in Castleman's disease thus seemed to be ineffective in predicting the disease behaviors.

AB - Castleman's disease is a morphologically and clinically heterogeneous lyrnphoproliferative disorder. Both hyaline vascular (HV) and plasma cell (PC) type were described. Systemic multicentric manifestation with a higher risk to develop malignant lymphoma was known in the latter type. Formaline-fixed, paraffin-embedded tissue from 15 Castleman's diseases were analyzed for clonal irnrnunoglobulin heavy chain rearrangement {IHR; by a semi-nest polymerase chain reaction (PCR) to amplify the complementary determining region III. As a sensitivity control, 92% of IHR detected by Southern blot analysis in malignant lymphoma was PCR positive. However, neither the HV (7 cases) or the PC (8 cases) type of and neither localized (7HVs and 2PCs) or multicentric (6PCs) Castleman's disease showed monoclonality. Clonality analysis in Castleman's disease thus seemed to be ineffective in predicting the disease behaviors.

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SN - 0301-472X

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JF - Experimental Hematology

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Clinical and molecular analyses of castleman's disease

Abstract

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