Clinical and Microbiological Characteristics of Bacteremic Pneumonia Caused by Klebsiella pneumoniae

I. Ren Chen, Shih Neng Lin, Xin Ni Wu, Sheng Hua Chou, Fu Der Wang, Yi Tsung Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Klebsiella pneumoniae is a common pathogen of nosocomial pneumonia worldwide and community-acquired pneumonia (CAP) in Asia. Previous studies have shown that K. pneumoniae bacteremic CAP is associated with high mortality. We aimed to revisit K. pneumoniae bacteremic pneumonia in the current era and determine the risk factors associated with 28-day mortality. Between January 2014 and August 2020, adult patients with K. pneumoniae bacteremic pneumonia in a medical center in Taiwan were identified. Clinical and microbiological characteristics were compared between CAP and nosocomial pneumonia. Risk factors for 28-day mortality were analyzed using multivariate logistic regression. Among 150 patients with K. pneumoniae bacteremic pneumonia, 52 had CAP and 98 had nosocomial pneumonia. The 28-day mortality was 52% for all patients, 36.5% for CAP, and 60.2% for nosocomial pneumonia. Hypervirulent K. pneumoniae was more prevalent in CAP (61.5%) than in nosocomial pneumonia (16.3%). Carbapenem-resistant K. pneumoniae was more prevalent in nosocomial pneumonia (58.2%) than in CAP (5.8%). Nosocomial pneumonia, a higher Severe Organ Failure Assessment score, and not receiving appropriate definitive therapy were independent risk factors for 28-day mortality. In conclusion, revisiting K. pneumoniae bacteremic pneumonia in the current era showed a high mortality rate. Host factors, disease severity, and timely effective therapy affect the treatment outcomes of these patients.

Original languageEnglish
Article number903682
JournalFrontiers in Cellular and Infection Microbiology
Volume12
DOIs
StatePublished - 23 Jun 2022

Keywords

  • bacteremia
  • community-acquired pneumonia (CAP)
  • Klebsiella pneumoniae
  • mortality
  • nosocomial pneumonia (NP)

Fingerprint

Dive into the research topics of 'Clinical and Microbiological Characteristics of Bacteremic Pneumonia Caused by Klebsiella pneumoniae'. Together they form a unique fingerprint.

Cite this