Cisd2 mediates mitochondrial integrity and life span in mammals

Yi Fan Chen, Cheng Heng Kao, Ralph Kirby, Ting Fen Tsai*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

50 Scopus citations


CISD2, the causative gene for Wolfram syndrome 2 (WFS2), is a previously uncharacterized novel gene. Using a mouse genetic approach, this work demonstrated for the first time that Cisd2 is involved in mammalian life span control. Cisd2 deficiency in mice leads to mitochondrial breakdown and dysfunction; this is accompanied by cell death with autophagic features and these events precede the two earliest manifestations of nerve and muscle degeneration. Together, they lead to a panel of phenotypic features suggestive of premature aging. This work effectively links Cisd2 gene function, mitochondrial integrity and aging in mammals.

Original languageEnglish
Pages (from-to)1043-1045
Number of pages3
Issue number7
StatePublished - 1 Oct 2009


  • Autophagy
  • Cisd2
  • Knockout mice
  • Mitochondria
  • Premature aging


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